Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system

Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β

“…Studies carried out recently by our group showed that the inhibition of water intake after third ventricle injections of IL-1b in the same doses used in the present study relied on an opioid-dependent mechanism, since the blockade of central opioid receptors by naloxone, a non-selective opioid antagonist, was able to suppress the antidipsogenic effect observed after central administration of this cytokine (Luz et al, 2006). A thorough literature review revealed no data on the subtypes of opioid receptors that could be mediating this behavioral effect of IL-1b at central level.…”

“…In a previous study we showed that central administration of IL-1b inhibits water and salt intake in rats in several different situations, and that this effect seems to depend on the functional integrity of the brain opiatergic system. Indeed, it was shown that, in rats, central administration of IL-1b inhibits water intake after dehydration, hyperosmolarity and hypovolemia, and that this antidipsogenic effect of IL-1b appears to rely on an opioid-dependent mechanism (Luz et al, 2006). We 0143-4179/$ -see front matter Ó 2009 Elsevier Ltd. All rights reserved.…”

Periodontal disease reduces water and sodium intake induced by injection of muscimol into the lateral parabrachial nucleus

“…23 In addition, peripheral and central administration of IL-1b, an immunoregulatory cytokine activated by LPS, inhibited water intake after dehydration, hyperosmolarity and hypovolaemia. 24 In the present study, we evaluated whether experimental ligature-induced PD inhibits thirst and sodium appetite induced by injection of muscimol into the LPBN. First, in order to check for general health, we monitored water and 0.3 M NaCl intake 3 and 16 days after ligature placement (Fig.…”

Thirst sensation and oral dryness following alcohol intake

“…In addition, acetaldehyde also secretes chymase from mast cells; however, rat chymase does not produce angiotensin II while human chymase activates the production [82], [83]. Cytokines released from mast cells, such as tumor necrosis factor (TNF)-α [84] and interleukin (IL)-1β [85], [86], [87], do not increase, but suppress water intake. In contrast, IL-6 has no effects [87].…”