Inhibition of vesicular stomatitis virus infection by nitric oxide

Bi, Zhengbiao; Reiss, Carol Shoshkes

doi:10.1128/jvi.69.4.2208-2213.1995

Cited by 153 publications

(71 citation statements)

References 47 publications

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“…These results are important for the understanding of the pathogenesis of PPV, and the use of PK-15 cells to study the inhibitory Our data demonstrated that the addition of SNAP and LA inhibited PPV replication in PK-15 cells in a dose-dependent manner. This finding is consistent with previous reports in which severe acute respiratory syndrome coronavirus (SARS-CoV) and vesicular stomatitis virus (VSV) were studied [5,25]. Although this reduction in viral replication is seen with NO itself, it is not certain whether the antiviral effects of SNAP or LA are actually due to some other NOrelated species.…”

supporting

confidence: 92%

Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro

et al. 2009

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This study investigated the inhibitory effect and mechanism of nitric oxide (NO) on porcine parvovirus (PPV) replication in PK-15 cells. The results showed that two NO-generating compounds, S-nitroso-L-acetylpenicillamine (SNAP) and L-arginine (LA), at a noncytotoxic concentration could reduce PPV replication in a dose-dependent manner and that this anti-PPV effect could be reversed by the NO synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME). By assaying the steps of the PPV life cycle, we also show that NO inhibits viral DNA and protein synthesis. This experiment provides a frame of reference for the study of the anti-viral mechanism of NO.

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supporting

confidence: 92%

Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro

et al. 2009

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“…ROS has a variety of defensive roles in the host, such as killing of intracellular pathogens, tumor cells, but also virus-infected cells (Hibbs et al, 1998;Keyaerts et al, 2004). The antiviral effects of NO − in particular have been previously reported (Bi and Reiss, 1995;Paludan et al, 1998;Ellermann-Eriksen, 2005). However, over expression of NO − , especially chronic, could have toxic side-effects also for the host cells (Brown, 2003).…”

Section: Discussionmentioning

confidence: 92%

Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection

Maragkoudakis

Chingwaru

Gradišnik

et al. 2010

International Journal of Food Microbiology

135

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This study aimed to examine the potential antiviral activity of lactic acid bacteria (LAB) using animal and human intestinal and macrophage cell line models of non tumor origin. To this end, LAB strains selected on the basis of previous in vitro trials were co-incubated with cell line monolayers, which were subsequently challenged with rotavirus (RV) and transmissible gastroenteritis virus (TGEV). In order to elucidate the possible mechanism responsible for the antiviral activity, the induction of reactive oxygen species (ROS) release as well as the attachment ability of LAB on the cell lines was investigated. Various strains were found to exhibit moderate to complete monolayer protection against viral RV or TGEV disruption. Highest protection effects were recorded with the known probiotics Lactobacillus rhamnosus GG and Lactobacillus casei Shirota against both RV and TGEV, while notable antiviral activity was also attributed to Enterococcus faecium PCK38, Lactobacillus fermentum ACA-DC179, Lactobacillus pentosus PCA227 and Lactobacillus plantarum PCA236 and PCS22, depending on the cell line and virus combination used. A variable increase (of up to 50%) on the release of NO(-) and H(2)O(2) (ROS) was obtained when LAB strains were co-incubated with the cell lines, but the results were found to be LAB strain and cell line specific, apart from a small number of strains which were able to induce strong ROS release in more than one cell line. In contrast, the ability of the examined LAB strains to attach to the cell line monolayers was LAB strain but not cell line specific. Highest attachment ability was observed with L. plantarum ACA-DC 146, L. paracasei subsp. tolerans ACA-DC 4037 and E. faecium PCD71. Clear indications on the nature of the antiviral effect were evident only in the case of the L. casei Shirota against TGEV and with L. plantarum PCA236 against both RV and TGEV. In the rest of the cases, each interaction was LAB-cell line-virus specific, barring general conclusions. However, it is probable that more than one mechanism is involved in the antiviral effect described here. Further investigations are required to elucidate the underlying mode of action and to develop a cell line model as a system for selection of probiotic strains suited for farm animal applications.

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“…Nitric oxide produced by NOS is associated with diverse actions in neurotransmission, vascular systems, and immunity, including antimicrobial and antiviral activities by way of inhibiting DNA as well as protein and lipid synthesis (Bredt and Snyder, 1994;Karupiah et al, 1993;Howe et al, 2002;Lepoivre et al, 1990). Thus, the NOS system is a very important component in innate immune system that is related directly to virus killing, such as poliovirus (Ló pez-Guerrero and Carrasco, 1998), picornavirus (Sanders et al, 1998), flavivirus (Kreil and Eibl, 1996), coronavirus (Lane et al, 1997), arenavirus (Campbell et al, 1994), rhabdovirus (Bi and Reiss, 1995), and ACID virus (Raber et al, 1996). As an innate immune effector, NOS can be induced to produce upregulation of NO in many invertebrates by the invasion of bacteria and parasites (Luckhart and Li, 2001;Dimopoulos et al, 2001;Nappi et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Modulatory effects of ammonia-N on the immune system of Penaeus japonicus to virulence of white spot syndrome virus

Jiang

Zhou

2004

Aquaculture

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To study response to white spot syndrome virus (WSSV) under ammonia stress, Penaeus japonicus were exposed to 5 mg l À1 ammonia-N and challenged orally with WSSV (NW). Controls consisted of an ammonia-N-exposed control group (N), a WSSV-challenged positive control group (W), and an untreated control group (control). Immune parameters measured were total haemocyte count (THC), haemocyte phagocytosis, plasma protein content and haemolymph enzymatic activities for prophenoloxidase (proPO), alkaline phosphatase (ALP), and nitric oxide synthase (NOS). THC and plasma protein had downward trends with time in all treatment groups (NW, N, and W) in contrast to the untreated control group (control). The percentage phagocytosis, NOS activity, and ALP and proPO activity of W and NW decreased initially then increased from 6 to 78 h (except for NOS and ALP, from 6 to 54 h) before declining thereafter until the end of the experiment. Compared with untreated controls (control), there was a downward trend for all measured parameters in the treatment groups (N, NW, and W), but the degree was WNNWNN. WSSV was detected at 78 h 0044-8486/$ -see front matter D postchallenge in both W and NW. In conclusion, 5 mg l À1 ammonia-N reduced the immunocompetence of P. japonicus and may have decreased the virulence of WSSV. D

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Inhibition of vesicular stomatitis virus infection by nitric oxide

Cited by 153 publications

References 47 publications

Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro

Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro

Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection

Modulatory effects of ammonia-N on the immune system of Penaeus japonicus to virulence of white spot syndrome virus

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