Inhibition of Vasopressin Action by Atrial Natriuretic Factor

Dillingham, Mark A.

doi:10.1126/science.3006248

Cited by 188 publications

(68 citation statements)

References 13 publications

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“…However, the effect of ANP (through an increase in cGMP) on sodium and fluid transport in the collecting duct is still controversial. Some earlier studies showed that it decreases both sodium reabsorption and vasopressin-induced water transport in collecting ducts (Dillingham and Anderson, 1986;Nonoguchi et al, 1988;Nonoguchi et al, 1989), whereas later studies do not confirm these inhibitory effects (Bouley et al, 2000;Rouch et al, 1991). This might probably due to the fact that ANP has a biphasic effects on renal water reabsorption process.…”

Section: Atrial Natriuretic Peptide (Anp)contrasting

confidence: 41%

Nephrogenic Diabetes Insipidus – The Novelly Potential Therapeutic Drugs

Chu¹,

Chow²

2011

Diabetes Insipidus

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Section: Atrial Natriuretic Peptide (Anp)contrasting

confidence: 41%

Nephrogenic Diabetes Insipidus – The Novelly Potential Therapeutic Drugs

Chu¹,

Chow²

2011

Diabetes Insipidus

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“…These divergent results may be due to strain differences. Nevertheless, because urine flow increased with ANP infusion in young animals in both studies, there may be age-related changes in direct ANP-mediated inhibition of vasopressin action on the tubule (23).…”

Section: Discussionmentioning

confidence: 99%

Renal Effects of Atrial Natriuretic Peptide Infusion in Young and Adult Rats

et al. 1988

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ABSTRAm. The immature kidney appears to be less GFR, glomerular filtration rate responsive to atrial natriuretic peptide (ANP) than the MAP, mean arterial pressure mature kidney. It has been proposed that this difference UeC~pV, urinary cGMP excretion accounts for the limited ability of the young animal to UN,V, urinary sodium excretion excrete a sodium load. To delineate the effects of age on the renal response to exogenous ANP, Sprague-Dawley rats were anesthetized for study at 31-32 days of age, 35-41 days of age, and adulthod. Synthetic rat A* was infused intravenously for 20 min at increasing doses ranging from 0.1 to 0.8 pg/kg/min, and mean arterial pressure, glomerular filtration rate, plasma ANP concentration, urine flow rate, and urine sodium excretion were measured at each dose. Since cyclic GMP acts as a second messenger for ANP action, urinary cyclic GMP excretion also was measured. Increasing doses of ANP caused a similar decrease in MAP at all ages studied, and increased glomerular filtration rate in adult but not young rats. Increasing the dose of ANP from 0.1 to 0.4 pg/kg/min caused a greater rise in urine flow and urinary cyclic GMP excretion in adult than young rats, and urine sodium excretion increased more in adults at all doses ( p < 0.05). However, the rise in plasma ANP concentration also was greater in adults than in young rats (p < 0.05), indicative of greater systemic clearance of ANP in young animals. Increasing levels of plasma ANP concentration were correlated with a greater rise in urine flow in adult than young (31-32 day old) rats ( p < 0.05), but there was no differential effect on urinary cyclic GMP excretion. We conclude that although the diuretic effect of ANP increases with age, the guanylate cyclase response to ANP does not change after 30 days of age in the rat. Decreasing clearance of ANP as rats age may be due to decreased enzymatic degradation of the peptide or reduced removal as a result of altered receptor binding. (Pediatr Res 24: 333-337,1988) Abbreviations ANP, atrial natriuretic peptide

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“…First, it is possible that the increased plasma ANH levels that further increased during water load in þMCE patients, inhibited the effect of relatively high AVP levels on urinary osmolality (21)(22)(23). Secondly, the inhibitory effect of high plasma concentrations of ANH on tubular sodium reabsorption and an ANH-induced increase in medullary blood flow in þMCE patients may have had an effect on the medullary osmotic gradient between interstitial fluid and the lumen of the collecting duct.…”

Section: Discussionmentioning

confidence: 99%

Impaired vasopressin suppression and enhanced atrial natriuretic hormone release following an acute water load in primary aldosteronism

Kimura

Yamamoto²,

Ohta³

et al. 1997

European Journal of Endocrinology

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The release of arginine vasopressin (AVP) and atrial natriuretic hormone (ANH) and their involvement in renal water and electrolyte metabolism in primary aldosteronism in humans were studied. An oral acute water load (20 ml/kg body weight) was given to each of 12 patients before and after surgical removal of their aldosterone-producing adenoma(s). Plasma AVP and ANH were measured simultaneously, and renal water and electrolyte metabolism and tubular functions were determined. The same water load was given to seven normal subjects and the same parameters were determined. In the presence of mineralocorticoid excess before the operation, plasma AVP was relatively low compared with plasma osmolality (Posm), but was not suppressed in response to decreases in Posm after the water load. Baseline plasma ANH was high and increased further after the water load; urinary dilution and diuresis both remained normal. After the operation, baseline plasma AVP was normal and decreased in response to the decrease in Posm after the water load, with normal urinary dilution and diuresis. Baseline plasma ANH was normal, and did not increase after the water load. The ratio of urinary K and Na clearances and distal tubular reabsorption of Na increased before the operation. These results suggest that there are perturbations of AVP and ANH release in primary aldosteronism, despite the normal urinary dilution after a water load. European Journal of Endocrinology 137 154-161

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Inhibition of Vasopressin Action by Atrial Natriuretic Factor

Cited by 188 publications

References 13 publications

Nephrogenic Diabetes Insipidus – The Novelly Potential Therapeutic Drugs

Nephrogenic Diabetes Insipidus – The Novelly Potential Therapeutic Drugs

Renal Effects of Atrial Natriuretic Peptide Infusion in Young and Adult Rats

Impaired vasopressin suppression and enhanced atrial natriuretic hormone release following an acute water load in primary aldosteronism

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