Inhibition of Type-2 Diabetes Mellitus Development by Sophocarpine through Targeting PPARy-Regulated Gene Expression

Su, Xiaoqian; Miao, Wei; Li, Li; Zheng, Haisheng; Hao, Gaimei; Du, Liang

doi:10.1134/s1607672921020150

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…Su et al tested the antidiabetic effect of sophocarpine in a mouse model of streptozotocin (STZ)-induced type 2 diabetes. They found that sophocarpine regulated blood glucose, insulin, LDL-c content and HDL-c levels while concurrently mitigating pancreatic injury and effectively impeding the advancement of type 2 diabetes by attenuating peroxisome proliferator-activated receptor gamma (PPARγ) activity in mice with type 2 diabetes ( Su et al, 2021 ). Although sophocarpine was shown to have beneficial effects in this study, further animal and human studies are needed to confirm and evaluate the role of sophocarpine in both type 1 and type 2 diabetes.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Many modern pharmacological studies have revealed its multiple bioactive effects, such as anticancer ( Luo et al, 2019 ), anti-inflammatory ( Gao et al, 2012 ), antiviral ( Gao et al, 2013 ; Sang et al, 2017 ), analgesic ( Wang et al, 2021b ), and organ protection ( Li et al, 2014 ; Hou et al, 2020 ) or addressing vessel dysfunction ( Fang et al, 2020 ) effects. Moreover, it also has an antidiabetic effect on type 1 diabetes ( Su et al, 2021 ). Furthermore, sophocarpine exhibits great benefits in agriculture.…”

Section: Introductionmentioning

confidence: 99%

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A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

Wei,

Xiao,

et al. 2024

Front. Pharmacol.

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Sophocarpine is a natural compound that belongs to the quinolizidine alkaloid family, and has a long history of use and widespread distribution in traditional Chinese herbal medicines such as Sophora alopecuroides L., Sophora flavescens Ait., and Sophora subprostrata. This article aims to summarize the pharmacology, pharmacokinetics, and toxicity of sophocarpine, evaluate its potential pharmacological effects in various diseases, and propose the necessity for further research and evaluation to promote its clinical application. A large number of studies have shown that it has anti-inflammatory, analgesic, antiviral, antiparasitic, anticancer, endocrine regulatory, and organ-protective effects as it modulates various signaling pathways, such as the NF-κB, MAPK, PI3K/AKT, and AMPK pathways. The distribution of sophocarpine in the body conforms to a two-compartment model, and sophocarpine can be detected in various tissues with a relatively short half-life. Although the pharmacological effects of sophocarpine have been confirmed, toxicity and safety assessments and reports on molecular mechanisms of its pharmacological actions have been limited. Given its significant pharmacological effects and potential clinical value, further research and evaluation are needed to promote the clinical application of sophocarpine.

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Section: Pharmacological Activitiesmentioning

confidence: 99%