Inhibition of tumour growth and metastasis of human fibrosarcoma cells HT-1080 by monoclonal antibody BCD-F9

Popkov, Mikhail; Sidrac-Ghali, Salwa; Lusignan, Y; Lemieux, Suzanne; Mandeville, Rosemonde

doi:10.1016/s0959-8049(01)00313-6

Cited by 5 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The efficacy of HmAbs in directing tumor cell killing in the presence of LAK cells was determined by an ADCC assay against MKN-45 and MKN-74 cells according to the methods described previously. 27,28 Briefly, after target cells (3 ϫ 10 4 ) were cultured for 48 hr in each well of 96-well plates, human LAK cells were added at the indicated effector:target ratios to each well in the presence of HmAbs or control IgG at 2 g/ml. After 6-hr incubation at 37°C in 5% CO 2 , the effector cells and dead tumor cells were removed by washing and the remaining living cells were then immediately quantified by the MTS assay.…”

Section: Adcc Assaymentioning

confidence: 99%

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

Imakiire

Shibaguchi

Abe

et al. 2003

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

Section: Adcc Assaymentioning

confidence: 99%

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

Imakiire

Shibaguchi

Abe

et al. 2003

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…This finding agrees with other highaffinity antibodies that bind effectively both high-and lowdensity antigen, whereas a low-affinity antibody only binds appreciably to high-density antigen because of its requirement for divalent attachment (28). This uptake is high enough to merit further evaluation in therapeutic trials (8,13,27,29,30). Via planar gamma camera imaging, A549 lung tumors as well as the LoVo colon tumors could be clearly visualized when tumors weighed f1 g. Moreover, even when A549 lung tumors were as small as 0.14 g, they were still clearly visible by planar gamma camera imaging.…”

mentioning

confidence: 99%

In vitro and In vivo Targeting Properties of Iodine-123- or Iodine-131–Labeled Monoclonal Antibody 14C5 in a Non–Small Cell Lung Cancer and Colon Carcinoma Model

Burvenich¹,

Schoonooghe²,

Cornelissen³

et al. 2005

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose:The monoclonal antibody (mAb) 14C5 is a murine IgG1directed against a yet undefined molecule involved in cell substrate adhesion found on the surface of malignant breast cancer tissue. mAb 14C5 is able to inhibit cell substrate adhesion and invasion of breast cancer cells in vitro. In normal tissues as well as in the stroma surrounding in situ carcinomas of the breast, no expression of the antigen 14C5 occurs. The aim of this study was to investigate the in vitro and in vivo targeting properties of

show abstract

“…The efficacy of HmAbs in directing tumor cell killing in the presence of LAK cells was determined by an ADCC assay against MKN‐45 and MKN‐74 cells according to the methods described previously 27, 28. Briefly, after target cells (3 × 10 4 ) were cultured for 48 hr in each well of 96‐well plates, human LAK cells were added at the indicated effector:target ratios to each well in the presence of HmAbs or control IgG at 2 μg/ml.…”

Section: Methodsmentioning

confidence: 99%

The effect of a low‐fat, high fiber, fruit and vegetable intervention on rectal mucosal proliferation

Pfeiffer

McShane

Wargovich

et al. 2003

Cancer

View full text Add to dashboard Cite

BACKGROUNDBecause studies of diet and colorectal carcinoma tend to be large and complex, researchers have long been interested in the investigation of dietary exposures in relation to putative intermediate markers of large bowel malignancy, such as colorectal epithelial cell proliferation. The basic hypothesis underlying these investigations is that specific dietary components may reduce or increase the rate of cell proliferation, which, in turn, may reduce or increase neoplastic changes in the large bowel.METHODSThe authors assessed the effects of a 4‐year, low‐fat, high‐fiber, fruit and vegetable‐enriched dietary intervention on colorectal epithelial cell proliferation among 399 participants from the Polyp Prevention Trial, a randomized multicenter trial with adenoma recurrence as the primary endpoint. Rectal biopsies were taken from flat, normal appearing mucosa on patients at baseline, after 1 year, and after 4 years. Two assays, bromodeoxyuridine (Brd U) and proliferating cell nuclear antigen (PCNA), were used to evaluate two summary measures of proliferation: the labeling index (LI) and the proliferative height (PH).RESULTSThere were no significant differences between changes in LI and PH over the 4‐year period for the intervention and control groups. This finding parallels the finding in the larger primary study, in which the dietary intervention did not alter adenoma recurrence rates.CONCLUSIONSA low‐fat, high‐fiber, fruit and vegetable‐enriched dietary intervention did not alter rectal mucosal cell proliferation rates. Cancer 2003;98:1161–8. Published 2003 by the American Cancer Society.DOI 10.1002/cncr.11608

show abstract

Inhibition of tumour growth and metastasis of human fibrosarcoma cells HT-1080 by monoclonal antibody BCD-F9

Cited by 5 publications

References 25 publications

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

In vitro and In vivo Targeting Properties of Iodine-123- or Iodine-131–Labeled Monoclonal Antibody 14C5 in a Non–Small Cell Lung Cancer and Colon Carcinoma Model

The effect of a low‐fat, high fiber, fruit and vegetable intervention on rectal mucosal proliferation

Contact Info

Product

Resources

About