Abstract:One Sentence Summary: Engineered chimeric toxin halts tumor growth in vivo via RAS cleavage Vidimar et al / Page 2 2 SummaryDespite nearly four decades of effort, broad inhibition of oncogenic RAS using small molecule approaches has proven to be a major challenge. Here we describe the development of a novel pan-RAS biologic inhibitor comprised of the RAS-RAP1-specific endopeptidase fused to the protein delivery machinery of diphtheria toxin. We show that this engineered chimeric toxin irreversibly cleaves and … Show more
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