Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

Caja, Sergio; Myrsky, Essi; Korponay-Szabó, Ilma Rita; Nadalutti, Cristina A.; Sulic, Ana-Marija; Lavrič, Miha; Sblattero, Daniele; Marzari, Roberto; Collighan, Russell; Mongeot, Alexandre; Griffin, Martin; Mäki, Markku; Kaukinen, Katri; Lindfors, Katri

doi:10.3109/00365520903540822

Cited by 17 publications

(12 citation statements)

References 27 publications

(46 reference statements)

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“…In this respect, our group has shown that celiac patients' autoantibodies that specifically target TG2 have the ability to inhibit angiogenesis in vitro 75 by increasing endothelial cell TG2 enzyme activity. 76 Moreover, our studies have also demonstrated that blood vessel permeability to macromolecules and lymphocytes in vitro is increased in the presence of patient-derived TG2 autoantibodies. 77 Therefore, the celiac disease-specific TG2-targeted autoantibodies deposited around mucosal blood vessels in the patients could contribute to the disorganization of the small-bowel vasculature and their increased permeability.…”

Section: The Role Of Celiac Disease Antibodies In the Pathogenesissupporting

confidence: 51%

“…80 In pregnancy, the umbilical cord and placental vasculature are vitally important as they assure efficient delivery of nutrients and other essential compounds to the growing embryo. Therefore, it can be envisaged that the effects of the celiac-specific autoantibodies on vascular biology [75][76][77] also contribute to adverse pregnancy outcomes.…”

Section: Antibodies In Celiac Diseasementioning

confidence: 99%

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Antibodies in celiac disease: implications beyond diagnostics

et al. 2011

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Section: The Role Of Celiac Disease Antibodies In the Pathogenesissupporting

confidence: 51%

Section: Antibodies In Celiac Diseasementioning

confidence: 99%

Antibodies in celiac disease: implications beyond diagnostics

et al. 2011

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“…Additionally, large quantities of anti-tTG2 predict the severity of pathologic stages. We know that anti-TG2 antibodies inhibit angiogenesis [8, 19]. Although antiapoptotic properties of anti-tTG2 antibodies were demonstrated, we do not understand the relationship between anti-tTG2 antibodies and proangiogenic and antiangiogenic molecules.…”

Section: Discussionmentioning

confidence: 98%

Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease

Akpınar

Aksoy²,

Sapmaz³

et al. 2019

Med Princ Pract

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Objective: Recent studies have demonstrated that angiogenesis is impaired in patients with celiac disease (CD). In this study, we evaluated the levels of the novel antiangiogenic factor pigment epithelium-derived factor (PEDF) in CD patients. Methods: Eighty-four patients were included in the study; 71 patients with CD and 13 healthy controls. In the CD patient cohort, there were 21 newly diagnosed patients, 19 with adherence to a gluten-free diet and 31 practicing no adherence to this diet. The PEDF levels were measured using enzyme-linked immunosorbent assays. Results: The data revealed that celiac patients had higher levels of PEDF than did healthy controls. PEDF levels were not significantly different among the three CD groups. Additionally, the PEDF levels were not correlated with tissue transglutaminase IgA or IgG. Conclusions: Our data indicate that PEDF levels are significantly higher in CD patients than those in the healthy controls. This result suggests that PEDF negatively affects angiogenesis in CD. Although we did not observe any differences of PEDF levels among celiac patients, additional studies including more patients could clarify this issue.

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“…Verdu et al [28] have shown that genetically predisposed individuals may exhibit an imbalance of the intestinal microbiota, increasing the immunological responses responsible for intestinal lesions, which would promote the onset of celiac disease. Other studies suggest that autoantibodies such as anti-transglutaminase antibodies may also modulate haemostasis of the small intestine, the onset of villous atrophy, which alter the permeability of the intestinal barrier and facilitate the passage of bacterial pathogens to colonize the intestinal mucosa [29,30]. …”

Section: Composition and Diversity Of Enterobacteries Genus In Intestmentioning

confidence: 99%

Characterization of <i>Enterobacteries</i> Genus in Intestinal Microbiota of Celiac Children

Lahcene¹,

Meddah²,

Bouziane-Nedjadi³

et al. 2017

IJCD

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The imbalance of the intestinal microbiota is link, by several diseases such as celiac disease, which causes inflammation in the small intestine. This inflammation is due by the digestion of gluten present in some type of cereals. In this work, fecal and duodenal biopsy samples were collected to characterize by conventional culture technique the composition of the Enterobacteries group in intestinal mirobiota of celiac children and were compared with control children. A significant difference detected in the intestinal flora of celiac children compared to controls children concerning the Enterobacteries group. We found an increase of E.coli, Enterobacter aerogeneses, and Klebsiella with presence of Salmonella sp, Shigella sp in biopsy and fecal samples of celiac children and a relationship between the increase of Enterobacter cloacea and the presence of positive anti-transglutaminase value.

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Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

Abstract: Since we found a significant negative correlation between endothelial cell angiogenesis and TG2 activity, we suggest that the anti-angiogenic effects of coeliac patient-derived TG2-targeted autoantibodies are exerted by enhanced enzymatic activity of TG2.

Cited by 17 publications

References 27 publications

Antibodies in celiac disease: implications beyond diagnostics

Antibodies in celiac disease: implications beyond diagnostics

Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease

Characterization of <i>Enterobacteries</i> Genus in Intestinal Microbiota of Celiac Children

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