INHIBITION OF TNF-α IMPROVES INDOMETHACIN (INDO)-INDUCED JEJUNOILEITIS IN RATS BY MODULATING INOS EXPRESSION

Saud, Bipin; Nandi, Jyotirmoy; Ong, Gilbert; Levine, Robert A.

doi:10.1111/j.1572-0241.2003.08525.x

American Journal of Gastroenterology

2003

DOI: 10.1111/j.1572-0241.2003.08525.x

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INHIBITION OF TNF-α IMPROVES INDOMETHACIN (INDO)-INDUCED JEJUNOILEITIS IN RATS BY MODULATING INOS EXPRESSION

Bipin Saud

Jyotirmoy Nandi

Gilbert Ong

et al.

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“…The disease’s pathology remains largely elusive. Clinical and experimental data point to an involvement of the TNF-alpha pathway and beneficial effects on its inhibition 5 6…”

mentioning

confidence: 99%

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura

Braun¹,

Suárez

Dinter

et al. 2019

BMJ Open Gastroenterol

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We describe the case of 50-year-old female patient who presented with severe gastrointestinal symptoms and progressive weight loss of unknown origin. Shortly after admission, she developed an acute flare of thrombotic thrombocytopaenic purpura (TTP) that had to be treated by plasma exchange therapy and rituximab administration. While the signs of TTP subsided, the gastrointestinal symptoms worsened with abdominal cramps, massive gastric retention, malnourishment and a stenosis due to extensive inflammation and wall thickening of the small bowel. Extensive diagnostic efforts yielded no specific cause, so the patient—based on the histopathological findings—was diagnosed with idiopathic non-granulomatous ulcerative jejunoileitis. Following a highly complicated clinical course over several months, successful remission of the inflammatory activity and recovery of the patient could be obtained by TNF-alpha blockade.

show abstract

“…The disease’s pathology remains largely elusive. Clinical and experimental data point to an involvement of the TNF-alpha pathway and beneficial effects on its inhibition 5 6…”

mentioning

confidence: 99%

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura

Braun¹,

Suárez

Dinter

et al. 2019

BMJ Open Gastroenterol

View full text Add to dashboard Cite

show abstract

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INHIBITION OF TNF-α IMPROVES INDOMETHACIN (INDO)-INDUCED JEJUNOILEITIS IN RATS BY MODULATING INOS EXPRESSION

Cited by 1 publication

References 0 publications

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura

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