2002
DOI: 10.1006/bbrc.2002.6476
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Inhibition of the Ubiquitin-Proteasome Pathway Induces Differential Heat-Shock Protein Response in Cardiomyocytes and Renders Early Cardiac Protection

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Cited by 80 publications
(57 citation statements)
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“…8 For induction of hypertrophy, nonconfluent cells were set serum-free for 24 hours and cultivated in M199 medium in the presence of hypertrophic agonists for 24 or 48 hours, either with 0.1% DMSO as a solvent control or with proteasome inhibitors. Representative data from single preparations are shown.…”
Section: Primary Cardiomyocyte Cell Culturementioning
confidence: 99%
“…8 For induction of hypertrophy, nonconfluent cells were set serum-free for 24 hours and cultivated in M199 medium in the presence of hypertrophic agonists for 24 or 48 hours, either with 0.1% DMSO as a solvent control or with proteasome inhibitors. Representative data from single preparations are shown.…”
Section: Primary Cardiomyocyte Cell Culturementioning
confidence: 99%
“…In both studies, peripheral leukocyte, but not myocardial, proteasome activity was determined, and thus it is not clear if the beneficial effect had any relation to myocardial proteasome. An additional study (204) has shown that preperfusion of isolated hearts with the proteasome inhibitor MG132 improves posthypoxic function of excised isolated papillary muscles. However, this was after a prehypoxic delay of at least 30 min with demonstrable increases in heat shock proteins but no determination of myocardial proteasome activity.…”
Section: Proteasome Dysfunction In Myocardial Ischemiamentioning
confidence: 99%
“…Cardiac myocytes were prepared as described previously. 13 After preplating for 2 hours, the adherent cardiac fibroblasts were cultivated under standard conditions in…”
Section: Cell Culturementioning
confidence: 99%