Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins

Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction

“…5) Previously, simvastatin was shown to disturbed Rab27a/Doc2a interaction. 6) Here we extend the study by Liu et al 4) to investigate whether zoledronate also disturbs Rab27a/Doc2a interaction during MC activation.…”

“…Simvastatin was previously shown to interfere Rab27a/ Doc2a interaction. 6) Zoledronate and simvastatin inhibition of HR are not affecting Ca 2+ mobilization and could be recovered by geranylgeraniol administration. 2,4,6) Zoledronate and simvastatin only inhibited histamine release after prolonged incubation (24 h).…”

“…6) Zoledronate and simvastatin inhibition of HR are not affecting Ca 2+ mobilization and could be recovered by geranylgeraniol administration. 2,4,6) Zoledronate and simvastatin only inhibited histamine release after prolonged incubation (24 h). This could be understood as both drugs interrupt the biochemical process that produces protein prenylation precursors.…”

“…All the experimental procedures performed in this study are available in Sahid et al 6) and Liu et al 4) Brief explanations are described below.…”

Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats

“…Another strategy to attenuate inflammation and oxidative stress depend on using lipidlowering agents such as statins (Sahid et al, 2017;Rodrigues et al, 2019). Simvastatin, a member of the statin group, inhibits rate-limiting enzymes in cholesterol biosynthesis.…”