Inhibition of the colony-forming capacity of human T-lymphocytes exerted by theophylline

Ghio, Riccardo; Scordamaglia, A; D’Elia, Piera; Pizzorno, Giuseppe; Romagnoli, Mathilde; Ciprandi, Giorgio; Canonica, Giorgio Walter

doi:10.1016/0192-0561(88)90062-8

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Homogenates of lymphocytes from the peripheral blood predominantly show PDE3 and PDE4 activities with no difference between CD4 and CD8 positive cells. In addition to its ability to inhibit mitogen‐induced and T‐cell antigen receptor (CD3)‐mediated proliferation of T lymphocytes in vitro [50, 51], theophylline enhances the suppression of autologous cell proliferation in mixed lymphocyte preparations [52], a phenomenon that is reflected by the induction in theophylline‐treated asthmatic subjects of an increased population of suppressor T cells [53, 54]. Theophylline also reduces cytokine release from T lymphocytes in vitro [51, 55], which may imply further actions on cytokine‐dependent functions of other leucocytes in vivo .…”

Section: Lymphocytesmentioning

confidence: 99%

Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease

Schmidt

Dent

Rabe

1999

Clin Experimental Allergy

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Theophylline is commonly used in the treatment of obstructive airway diseases. The identification and functional characterization of different phosphodiesterase (PDE) isoenzymes has led to the development of various isoenzyme-selective inhibitors as potential anti-asthma drugs. Considering the distribution of isoenzymes in target tissues, with high activity of PDE3 and PDE4 in airway smooth muscle and inflammatory cells, selective inhibitors of these isoenzymes may add to the therapy of chronic airflow obstruction. However, initial data from clinical trials with selective PDE3 and PDE4 inhibitors have been somewhat disappointing and have tempered the expectations considerably since these drugs had limited efficacy and their use was clinically limited through side effects. The improved understanding of the molecular biology of PDEs enabled the synthesis of novel drugs with an improved risk/benefit ratio. These 'second generation' selective drugs have produced more promising clinical results not only for the treatment of bronchial asthma but also for the treatment of chronic obstructive pulmonary disease.

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Section: Lymphocytesmentioning

confidence: 99%

Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease

Schmidt

Dent

Rabe

1999

Clin Experimental Allergy

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“…Our studies have further shown the theophylline inhibition of the immune response to be dose dependent, and more sophisticated experiments indicate that the "once a day" administration of theophylline (35), should be warmly advocated (12,32).…”

Section: G W Canonica and G Ciprandimentioning

confidence: 99%

“…However, since previous studies have shown interaction between glucocorticosteroids, theophylline, ketotifen, or adrenergic agents and the immune system (1,9,11,12,24,26,27,32), we considered it useful to investigate the possible effects of other compounds employed in these disorders in order to obtain additional experimental data concerning these same drugs and, consequently, their proper clinical use.…”

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confidence: 99%

Antiallergic drugs and the immune response

Canonica

Ciprandi

1989

Allergy

Self Cite

112

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Re V. MSince the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy and possible concomitant infections, we have investigated the possible effects of such drugs as cromolyn, theophylline, ketotifen, oxatomide, astemizole, fenoterol, pirenzepine, and rosaprostol on the in vitro immune response, in order to obtain experimental data and, as a consequence, clinical conclusions. In a series of investigations by our group and other authors the following immunological parameters have been considered: T cell activation induced by different pathways (i.e. autologous stimulation, PHA, anti-CD3, -CD2 and -CD28 monoclonal antibodies), and lymphokine production (i.e. IL-1, IL-2 and gamma-IFN). For a more detailed experimental model the experiments have been performed both in bulk culture and by using T cell clones derived from the peripheral blood. The results show cromolyn to have an enhancing effect, theophylline and ketotifen a suppressing effect, whereas the remainder show no effect on the immune response. These data are considered and discussed from the aspect of their possible clinical relevance and also in light of the in vivo data previously reported.

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Effects of Theophylline and Non-selective Xanthine Derivatives on PDE Isoenzymes and Cellular Function

Dent¹,

Rabe²

1996

Phosphodiesterase Inhibitors

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Inhibition of the colony-forming capacity of human T-lymphocytes exerted by theophylline

Cited by 7 publications

References 6 publications

Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease

Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease

Antiallergic drugs and the immune response

Effects of Theophylline and Non-selective Xanthine Derivatives on PDE Isoenzymes and Cellular Function

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