Inhibition of testicular growth in rainbow trout <i>(Oncorhynchus mykiss)</i> exposed to estrogenic alkylphenolic chemicals

Jobling, Susan; Sumpter, John P.; Sheahan, Dave; Osborne, Julia A.; Matthiessen, Peter

doi:10.1002/etc.5620150218

Cited by 1,023 publications

(226 citation statements)

References 50 publications

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“…In addition, in previous work we identified nonionic surfactants in an herbicide 'spreader' formulation [24], which is added to herbicide formulations to increase herbicide efficacy [24]. Alkylphenol polyethoxylate surfactants are toxic to aquatic organisms [29] [30] and their degradation products, namely alkylphenols, elicit estrogenic responses in aquatic organisms [31][32][33][34][35]. As a result of FAB/MS identifications, subsequent studies were designed to determine the fate of the nonylphenol polyethoxylates using quantitative analytical methods based on high performance liquid chromatography.…”

Section: Resultsmentioning

confidence: 99%

Identifying Hydrocarbon and Fluorocarbon Surfactants in Specialty Chemical Formulations of Environmental Interest by Fast Atom Bombardment/Mass Spectrometry

Field¹,

Schultz²,

Barofsky³

2003

Chimia

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Hydrocarbon-and fluorocarbon-based surfactants are used in specialty or 'niche' chemical formulations that are designed for applications such as aircraft deicing and anti-icing, 'spreaders' that increase the effectiveness of pesticide formulations, and for fighting hydrocarbon-fuel fires. The identity of the surfactants in specialty formulations is usually proprietary information. However, this information is needed to design studies that monitor the occurrence and fate of all the components of specialty chemical formulations that enter the environment and pose a risk toward aquatic organisms. Fast atom bombardment/mass spectrometry (FAB/MS), while not a new technique, remains the fastest technique for identifying surfactants in complex mixtures because no sample preparation is required. FAB/MS was applied to samples of an aircraft deicer and anti-icer and aqueous-film-forming-foams (AFFF) for the purpose of identifying the major classes of hydrocarbon and fluorocarbon surfactants. High mass accuracy FAB/MS measurements were made to identify an unknown fluorosurfactant in an AFFF formulation. Rapid identification of surfactants that are released into the environment facilitates the subsequent selection of quantitative analytical methods that can be used to monitor the occurrence and fate of surfactants in the environment.

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Section: Resultsmentioning

confidence: 99%

Identifying Hydrocarbon and Fluorocarbon Surfactants in Specialty Chemical Formulations of Environmental Interest by Fast Atom Bombardment/Mass Spectrometry

Field¹,

Schultz²,

Barofsky³

2003

Chimia

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“…Jobling et al . [121] using rainbow trout ( Oncorhychus mykiss ) and alkylphenolic chemicals; Donohoe and Curtis [122] using juvenile rainbow trout, o, p '-DDT and o, p '-DDE; Schwaiger et al . [123] using rainbow trout, common carp ( Carpio carpio ) and NP; and Janssen et al .…”

Section: Molecular Mechanisms For Oogenic Protein Gene Expressionmentioning

confidence: 99%

“…Another possible deleterious effect is that high Vtg and/or Zr p concentrations might cause kidney failure and increased mortality rates as a result of metabolic stress [163]. Furthermore, although not yet demonstrated, there is a possibility that the reduced testicular growth could reduce fertility [121]. …”

Section: Molecular Mechanisms For Oogenic Protein Gene Expressionmentioning

confidence: 99%

Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption

2003

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The oocyte is the starting point for a new generation. Most of the machinery for DNA and protein synthesis needed for the developing embryo is made autonomously by the fertilized oocyte. However, in fish and in many other oviparous vertebrates, the major constituents of the egg, i.e. yolk and eggshell proteins, are synthesized in the liver and transported to the oocyte for uptake. Vitellogenesis, the process of yolk protein (vitellogenin) synthesis, transport, and uptake into the oocyte, and zonagenesis, the synthesis of eggshell zona radiata proteins, their transport and deposition by the maturing oocyte, are important aspects of oogenesis. The many molecular events involved in these processes require tight, coordinated regulation that is under strict endocrine control, with the female sex steroid hormone estradiol-17β in a central role. The ability of many synthetic chemical compounds to mimic this estrogen can lead to unscheduled hepatic synthesis of vitellogenin and zona radiata proteins, with potentially detrimental effects to the adult, the egg, the developing embryo and, hence, to the recruitment to the fish population. This has led to the development of specific and sensitive assays for these proteins in fish, and the application of vitellogenin and zona radiata proteins as informative biomarkers for endocrine disrupting effects of chemicals and effluents using fish as test organisms. The genes encoding these important reproductive proteins are conserved in the animal kingdom and are products of several hundred million years of evolution.

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“…Aquatic organisms exposed to these types of EDCs display phenotypes produced by exposure to natural estrogens (xenoestrogens) [67]- [69]. For example, in direct toxicity experiments, xenoestrogens have been shown to effect fish gonadal size [70]- [72] and maturation [73]. Furthermore, perfluorinated compounds (PFCs), chemicals widely used in lubricants and polymers, have been shown to alter sex ratios in the offspring of zebrafish exposed to PFCs [74].…”

Section: Observed Phenotypic Outcomes In Direct Toxicological Studiesmentioning

confidence: 99%

Expanding the Indicator Bacteria Concept: A Novel Approach to Assess Ecosystem Risk in Impaired Waters

Carrara¹,

Settell²,

Andrews³

et al. 2015

JWARP

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Many studies report the relationship between coliform indicator bacteria levels and the overall quality of environmental water for public use. This study, an outgrowth of a long-term watermonitoring program within the upper Appomattox River (Virginia) watershed, employs a zebrafish model to examine the relationship between impaired stream water and aquatic vertebrate development. We report results that suggest an expansion of the indicator bacteria concept, showing a possible relationship between waters containing high levels of the indicator bacterium, Escherichia coli (E. coli), with developmental defects upon zebrafish embryos. These effects are not directly attributable to bacterial presence, as filtered test waters void of bacteria produce the same results in embryos, indicating these developmental defects are due to the presence of other toxins or contaminants. Fish embryos exposed to the test waters show reduced survivorship and altered brain and heart development. Furthermore, fish surviving to adulthood exhibit altered gonads and skewed sex ratios. We suggest that this broadly focused approach examining the complex interactions (biotic and abiotic) within raw water sources could be used in conjunction with traditional chemical assays and/or dose-response studies on vertebrate models for a more complete analysis of stream water quality conditions.

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Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals

Cited by 1,023 publications

References 50 publications

Identifying Hydrocarbon and Fluorocarbon Surfactants in Specialty Chemical Formulations of Environmental Interest by Fast Atom Bombardment/Mass Spectrometry

Identifying Hydrocarbon and Fluorocarbon Surfactants in Specialty Chemical Formulations of Environmental Interest by Fast Atom Bombardment/Mass Spectrometry

Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption

Expanding the Indicator Bacteria Concept: A Novel Approach to Assess Ecosystem Risk in Impaired Waters

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