Inhibition of sympathetic activity induced by losartan in essential hypertensives.

Cottone, S.

doi:10.1016/s0895-7061(99)80420-8

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Angiotensin-converting Enzyme (Ace) Inhibitors and Aii Antag1

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2002

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“…Studies with the angiotensin II receptor antagonists indicate a sympathoplegic effect similar to that of the ACE inhibitors. 20 In one CHF study ELITE I, Q-T dispersion, a marker of both neural tone and ventricular irritability, was raised in patients treated with the ACE inhibitor, captopril, but not after losartan. The lower rate of death and sudden death rate in ELITE I after losartan-treated patients suggested that the ARB lowered ventricular irritability, 21 but this effect was absent in ELITE II.…”

Section: Angiotensin-converting Enzyme (Ace) Inhibitors and Aii Antagmentioning

confidence: 99%

Sympatholytic therapy in primary hypertension: a user friendly role for the future

DeQuattro

2002

J Hum Hypertens

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Effective therapy (Rx) in primary hypertension (PH) for 50 years, has featured sympathetic nervous system (SNS) mechanisms. Ganglionic blockers and reserpine were pre-eminent in the 1940s (mydriasis, ileus, impotence, peptic ulcer). Guanethidine, and in the 1960s clonidine and methyldopa, were step II agents to thiazide Rx in the 1950s. Reserpine depletes brain (depression) and peripheral (PPH) noradrenaline (NA) storage sites, guanethidine depleted NA storage via blockade of reuptake. Venomotor sympathoplegia resulted in postural hypertension. An analogue, metaiodobenzyguandine is used in diagnosis and Rx of pheochromocytoma. Clonidine lowers both central and PPH neuronal NA release via both stimulation of ␣ agonist adrenoreceptors (sedation) and specific imadazoline binding sites (IBS). Methyldopa lowers pressure via PPH

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Section: Angiotensin-converting Enzyme (Ace) Inhibitors and Aii Antagmentioning

confidence: 99%

Sympatholytic therapy in primary hypertension: a user friendly role for the future

DeQuattro

2002

J Hum Hypertens

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Inhibition of sympathetic activity induced by losartan in essential hypertensives.

Cited by 1 publication

References 0 publications

Sympatholytic therapy in primary hypertension: a user friendly role for the future

Sympatholytic therapy in primary hypertension: a user friendly role for the future

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