Inhibition of Sulfathiazole Crystal Growth by Polyvinylpyrrolidone

Simonelli, Anthony P.; Mehta, Surendra C.; Higuchi, William I.

doi:10.1002/jps.2600590512

Cited by 170 publications

(83 citation statements)

References 7 publications

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“…The explanation can be the high amount of PVPK30 helped in maintaining the drug in amorphous form (Simonelli, Metha, and Higuchi 1970;Hammad and Muller 1998) for 1 month had similar dissolution rate compared with initial formulations (Figure 14). In with solid solution, however, after 1 month slower dissolution rate was obtained compared with the initial samples.…”

Section: Stability Studiesmentioning

confidence: 97%

Improving the Dissolution Rate of Poorly Water Soluble Drug by Solid Dispersion and Solid Solution—Pros and Cons

et al. 2007

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Section: Stability Studiesmentioning

confidence: 97%

Improving the Dissolution Rate of Poorly Water Soluble Drug by Solid Dispersion and Solid Solution—Pros and Cons

et al. 2007

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“…Most reports indicate that nucleation and crystal growth are delayed due to drug-polymer interactions in solution and by adsorption of the polymer on the nucleus or the growing crystal. [58,94,95] Some polymers that have been thoroughly investigated for their stabilizing characteristics are PVP, PEG, methylcellulose (MC) and HPMC. [57][58][59]93] Above their critical micellar concentration, surfactants will solubilize poorly soluble compounds and thereby decrease the degree of supersaturation.…”

Section: Crystal Growthmentioning

confidence: 99%

Review: physical chemistry of solid dispersions

2009

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Objectives With poorly soluble drug candidates emerging in the drug discovery pipeline, the importance of the solid dispersion formulation approach is increasing. This strategy includes complete removal of drug crystallinity, and molecular dispersion of the poorly soluble compound in a hydrophilic polymeric carrier. The potential of this technique to increase oral absorption and hence bioavailability is enormous. Nevertheless, some issues have to be considered regarding thermodynamic instability, as well in supersaturated solutions that are formed upon dissolution as in the solid state. Key findings After a brief discussion on the historical background of solid dispersions and their current role in formulation, an overview will be given on the physical chemistry and stability of glass solutions as they form supersaturated solutions, and during their shelf life. Conclusions Thorough understanding of these aspects will elicit conscious evaluation of carrier properties and eventually facilitate rational excipient selection. Thus, full exploitation of the solid dispersion strategy may provide an appropriate answer to drug attrition due to low aqueous solubility in later stages of development.

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“…The objective of the present work is to apply the concept of a triple "C" solid dispersion system to the binary solid dispersion system of sulfathiazole and polyvinylpyrrolidone (PVP), which had been studied previously for its stability and dissolution characteristics (21,22). The term triple "C" solid dispersion system, called an internal ternary solid dispersion (ITSD) system herein, represents an innovative way to combine the advantages of both conventional solid dispersion and surface solid dispersion by utilizing the adsorptive nature of porous fine silica materials to improve the particle size and by modifying the model drug into an optimal molecular form.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Patel¹,

Dave²

2013

AAPS PharmSciTech

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Abstract. Colloidal solid dispersion is an innovative breakthrough in the pharmaceutical industry that overcomes the solubility-related issue of poorly soluble drugs by using an amorphous approach and also the stability-related issue by means of a complex formation phenomenon using different carrier materials. In the present study, a newly developed adsorption method is introduced to incorporate a high-energy sulfathiazole-polyvinylpyrrolidone (Plasdone® K-29/32) solid dispersion on porous silicon dioxide (Syloid® 244FP). Different ternary systems of sulfathiazole-Plasdone® K-29/32-Syloid® 244FP were prepared (1:1:2, 1:1:3, and 1:2:2) and categorized depending on the mechanism by which Syloid® 244FP was incorporated. Modulated differential scanning calorimetry (MDSC), X-ray diffraction, Fourier transform infrared spectroscopy, and in vitro dissolution studies were conducted to characterize the ternary systems. The X-ray diffraction and MDSC data showed a lack of crystallinity in all internal and external ternary systems, suggesting a loss of the crystallinity of sulfathiazole compared to the physical mixtures. USP apparatus II was used to measure the in vitro dissolution rate of the prepared systems at 75 rpm in different media. The dissolution rate of the optimum ratio (1:2:2) containing an internal ternary solid dispersion system was found to be three times higher than that of the external and physical systems. Thus, the porous silicon dioxide incorporated into the conventional binary solid dispersion acted as a carrier to disperse the complex and increase the dissolution rate.

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Inhibition of Sulfathiazole Crystal Growth by Polyvinylpyrrolidone

Cited by 170 publications

References 7 publications

Improving the Dissolution Rate of Poorly Water Soluble Drug by Solid Dispersion and Solid Solution—Pros and Cons

Improving the Dissolution Rate of Poorly Water Soluble Drug by Solid Dispersion and Solid Solution—Pros and Cons

Review: physical chemistry of solid dispersions

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

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