Inhibition of suicidal erythrocyte death by resveratrol

Qadri, Syed M.; Föller, Michael; Läng, Florian

doi:10.1016/j.lfs.2009.04.015

Cited by 30 publications

(27 citation statements)

References 84 publications

(67 reference statements)

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“…Resveratrol is a member of the phytoalexin family, which are low molecular weight, secondary metabolites produced by plants as a defensive mechanism against certain stresses, such as attack by pathogens, wounds and ultraviolet irradiation. Numerous studies in the literature have indicated that resveratrol exhibits anticancer, anti-inflammatory, anti-oxidative and antiasthmatic effects (26,27,35,36), suppresses metastasis in several cancers (37), inhibits platelet aggregation in cardiovascular diseases, and regulates mucin, inflammatory mediators [monocyte chemoattractant protein-1, interleukin (IL)-6 and IL-8] and matrix-metalloprotease-9 expression in chronic obstructive pulmonary disease (38)(39)(40). Another study revealed that resveratrol inhibits the Hh signaling pathway in prostate cancer (32).…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

et al. 2015

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Abstract. The hedgehog (Hh) signaling pathway is vital to vertebrate development, the homeostatic process and tumorigenesis. Epithelial-mesenchymal transition (EMT) is a cellular process during which epithelial cells become mesenchymal-appearing cells, which in turn promotes cancer metastasis and invasion. Resveratrol is a natural polyphenolic compound found in grapes, a variety of berries, peanuts and other plants. Numerous studies have demonstrated that the Hh signaling pathway is able to regulate the EMT, and that resveratrol can suppress carcinoma invasion and metastasis. In addition, certain studies have indicated that resveratrol can inhibit the Hh signaling pathway and EMT in cancers other than gastric cancer. The purpose of the present study was to investigate the inhibitory effect of resveratrol on the Hh signaling pathway and EMT in gastric cancer in vitro. Gastric cancer SGC-7901 cells were treated with resveratrol or cyclopamine at different concentrations. The viability of the cells was assessed using an MTT assay. The expression of Gli-1, a key component of the Hh signaling pathway, and Snail, E-cadherin and N-cadherin, key components of EMT, was detected by reverse transcription polymerase chain reaction (RT-PCR) and western blotting. The invasion and metastasis of the cells were observed by performing a cell scratch test. The RT-PCR and western blotting showed a decrease in Gli-1, Snail and N-cadherin expression, and an increase in E-cadherin expression in the resveratrol and cyclopamine group compared with the control group, suggesting that resveratrol inhibited the Hh pathway and EMT, as did cyclopamine. The MTT assay indicated that the viability of the SGC-7901 cells was significantly decreased in a concentration-dependent manner following resveratrol and cyclopamine treatment. The cell scratch test showed slower cell invasion and metastasis in the resveratrol and cyclopamine groups. These findings indicated that resveratrol was able to inhibit the Hh signaling pathway and EMT, and suppress invasion and metastasis in gastric cancer in vitro.

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Section: Discussionmentioning

confidence: 99%

“…Resveratrol exhibits a number of beneficial health effects, including anti-inflammatory, anti-oxidant, cardioprotective and anti-tumor properties (26,27), as well as affecting tumorigenesis and tumor progression (28).…”

Section: Resveratrol Inhibits the Hedgehogmentioning

confidence: 99%

Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

et al. 2015

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“…The consequent increased cytosolic Ca 2+ concentration, combined with oxidative stress and energy depletion, can generate eryptosis (erythrocyte death) [243]. This process can be inhibited by resveratrol (3,5,4'-trihydroxy-trans-stilbene), a natural phenol produced by several plants, which use this phenol to protect themselves from bacteria and fungi.…”

Section: (4) Cell-cell Communication and Anticancer Treatmentmentioning

confidence: 99%

Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

Brücher

Jamall

2014

Cell Physiol Biochem

176

161

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The delineation of key molecular pathways has enhanced our knowledge of the biology of tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell-cell communication and the possibilities for modulation provide new opportunities for treating cancers. Cells communicate by direct and indirect signaling. Direct cell-cell communication involves both, self-self-communication (intracrine and autocrine), and adjacent communication with nearby cells (juxtacrine), which themselves are regulated by distinct pathways. Indirect intercellular communication involves local communication over short distances (paracrine and synaptic signaling) or over large distances via hormones (endocrine). The essential components of cell-cell communication involve communication junctions (Connexins, Plasmodesmata, Ion Channels, Chemical Synapses, and Pannexins), occluding junctions (Tight Junctions), and anchoring junctions (Adherens, Desmosomes, Focal Adhesions, and Hemidesmosomes). The communication pathways pass through junctions at physical cell-cell attachments, and they go, as well, through the extracellular matrix (ECM) via the different transmembrane adhesion proteins (Cadherins and Integrins). We have here reviewed cell-cell communication involving (1) the components of junctions and their dynamic interplay with the other aspects of communication, including (2) the tumor microenvironment and carcinogenesis, (3) coupling and migration, (4) the underlying cell-cell and sub-cellular communication mechanisms (signaling) of anticancer treatments, and finally, (5) aspects of recent research on cell-cell communication.

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“…Оксида-тивний стрес є найбільш відомим тригером ериптозу [2]. Можливо, у зв`язку зі значним підсиленням вільнорадикальних процесів з віком і пов'язано зниження стійкості ери-троцитів до пошкоджувальних агентів, що спостерігається у старих організмів [3][4][5] (яка може відновлюватися введенням антиок-сидантів [6]). Одним з найбільш поширених в організмі пошкоджувальних агентів для мембран еритроцитів є закиснення середо-вища у зв'язку з порушенням тканинного дихання (гіпоксія, ішемія тощо), тому як тест на стійкість мембран еритроцитів було обрано відомий кислотний гемоліз.…”

Section: вступunclassified

Restoration of Erythrocytes Stability to Acid Hemolysis by Сerium Oxide Nanoparticles in Old Rats

Kotsuruba¹,

Kopjak²,

Сагач³

et al. 2014

Fiziol Zh

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Inhibition of suicidal erythrocyte death by resveratrol

Cited by 30 publications

References 84 publications

Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

Restoration of Erythrocytes Stability to Acid Hemolysis by Сerium Oxide Nanoparticles in Old Rats

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