Inhibition of Steroid 5α‐Reductase Activity by Aliphatic Fatty Acids

Anti‐Androgenic Activity of Fatty Acids

“…This result suggested that the 5a-reductase inhibitory activity of saturated fatty acids depends on the hydrocarbon-chain length. This result was similar to those reported by Niederprüm et al [14]. When C 18 fatty acids were investigated, only the unsaturated compounds showed 5a-reductase inhibitory activity of greater than 50% inhibition at the concentration of 1.3 mm (Figs.…”

“…The complete reaction mixture included 1 mm dithiothreitol, 20 mm phosphate buffer (pH 6.5), 1.9 nCi [4-14 C]testosterone (0.7 mm), 150 mm testosterone, 167 mm NADPH, and the microsomes (0.6 mg of protein) in a final volume of 0.3 ml. The concentration of testosterone contributed by [4][5][6][7][8][9][10][11][12][13][14] C]testosterone was negligible. The sample was added to the soln.…”

“…The radioactivity profile was determined with an imaging analyzer (FLA-5000 RF, Fuji Film Co., Ltd. Tokyo, Japan). The 5a-reductase activity was calculated from the percentage of the extent of the conversion of [4-14 C]testosterone to [4][5][6][7][8][9][10][11][12][13][14] C]dihydrotestosterone.…”

“…solvents were purchased from Wako Pure Chemical Industries Co. (Osaka, Japan). [4][5][6][7][8][9][10][11][12][13][14] C]Testosterone was obtained from Perkin-Elmer Japan Co., Ltd. (Kanagawa, Japan). Preparation of Rat Microsomes.…”

Fatty Acid Composition and Oil Yield in Fruits of Five Arecaceae Species Grown in Cuba

“…The highest content of lauric and myristic acids was observed in Thrinax radiata oil, which on the other hand, showed the lowest content of oleic and linoleic acids. Although this palm has a low oil yield, its high lauric and myristic acid content could be interesting as they demonstrated pharmacological activity in both forms, in the free form and in the ester form [5,14].…”