Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus by rhodomyrtone, a novel antibiotic candidate

Leejae, Sukanlaya; Hasap, Laila; Voravuthikunchai, Supayang Piyawan

doi:10.1099/jmm.0.047316-0

Cited by 81 publications

(64 citation statements)

References 55 publications

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“…S. aureus was incubated with rhodomyrtone at 0.5×MIC (0.25 μg/ml) to assess the susceptibility of rhodomyrtone-treated cells compared with untreated cells at different concentrations of oxidants (H 2 O 2 ) in vitro. The results show that the untreated normal S. aureus cells had a better rate of survival than the cells that were treated with rhodomyrtone as a result of the reduced pigmentation of the cells after incubation with rhodomyrtone [38]. The authors also indicated that the bacterial cell membrane and subsequent cell lysis were not the main target of rhodomyrtone, as the compound had no significant effect on either of them [38].…”

Section: Antibacterial Activitymentioning

confidence: 98%

“…[22] Taraxerol (32) [29] Trans-triacontyl-4-hydroxycinnamate (33) [26] 3,3',4,4'-tetra-O-methylflavellagic acid (34) [26] 3-O-(E)-coumaroyloleanolic acid (35) [26] (-)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol (36) [26] Arjunolic acid (37) [26] 4-hydroxy-3-methoxybenzoic acid (38) [26] Stigmast-4-en-3-one (39) [26] Oleanolic acid (40) [26] Methyl gallate (41) [26] 3-O-methylellagic acid 4-O-rhamnopyranoside (42) [26] …”

Section: Antifungal Activitymentioning

confidence: 99%

“…(37) (38) and nuclear lysates from RAW264.7 cells and mice, revealed that the methanolic extract of R. tomentosa was capable of suppressing the activation of both nuclear factor-kB and activator protein-1 pathways by directly targeting spleen tyrosine kinase/proto-oncogene tyrosineprotein kinase (Syk/Src) and interleukin-1 receptor-associated kinase 1/interleukin-1 receptor-associated kinase 4 (IRAK1/IRAK4).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review

Hamid

Zeyohannes²,

Yusoff³

2016

Asian J Pharm Clin Res

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Rhodomyrtus tomentosa is a common wood, prevalent in areas with undemanding soil conditions and resistant toward pests and diseases. The plant can be found in China, Taiwan, Philippines, Malaysia, Indonesia, and Vietnam. Literature and artwork indicate that R. tomentosa played an important holistic role in the daily lives of several ancient cultures, providing medicinal benefits. R. tomentosa exhibits a wide spectrum of pharmacological effects and has been used to treat colic diarrhea, wounds, heartburn, abscesses, gynecopathy, and as a pain killer. R. tomentosa was used in traditional Chinese medicine to treat urinary tract infection. 42 compounds have been isolated from this plant and structurally elucidated. They comprise phloroglucinol, flavonoid, terpenoid, anthracene glycoside, tannin, and other compounds. Rhodomyrtone, a member of the acylphloroglucinols demonstrated a significant activity against a wide range of Gram-positive bacteria. Rhodomyrtone exhibited both antimicrobial and anti-infective activities. Several biological activities have been documented as antibacterial, antifungal, antimalarial, osteogenic, antioxidant, and anti-inflammatory. R. tomentosa has been studied extensively for alternative antimicrobial agents. Although rhodomyrtone exhibited potential activity with a very low minimum inhibitory concentration value, the mechanisms of action of this compound are still unclear. Furthermore, toxicity studies on it extract to validate pharmacological activities are required.

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Section: Antibacterial Activitymentioning

confidence: 98%

Section: Antifungal Activitymentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review

Hamid

Zeyohannes²,

Yusoff³

2016

Asian J Pharm Clin Res

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“…In this study, many factors were taken into account, including the type of microbiological medium, the use of various peptide stock solution solvents, and the impact of lipopeptide cyclization proved that the membranes of staphylococci grown in MH were less fluid than cells grown in BHI or TSB, which was related to a higher content of branched-chain fatty acids (BCFAs) and carotenoids [19]. These findings may be much more interesting as the staphyloxanthin, a carotenoid pigment, is one of the most potent virulence factors of S. aureus [20]. Staphyloxanthin provides integrity of the cell membrane and improves the resistance to reactive oxygen species this enhancing bacterial survival [21][22][23].…”

Section: Discussionmentioning

confidence: 92%

Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media

Jaśkiewicz¹,

Neubauer²,

Kamysz³

2017

Preprint

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Staphylococcus aureus bacteria are one of the leading microorganisms responsible for nosocomial infections as well as being the primary causative pathogen of skin and wound infections. Currently, the therapy of staphylococcal diseases faces many difficulties, due to a variety of mechanisms of resistance and virulence factors. Moreover, a number of infections caused by S. aureus is connected with biofilm formation that impairs effectiveness of the therapy. Short cationic lipopeptides that are designed on the basis of the structure of antimicrobial peptides structure are likely to provide a promising alternative to conventional antibiotics. Despite the fact that many research groups have proved a high antistaphylococcal potential of lipopeptides, the lack of unified protocols in determination of antimicrobial activity may be the reason of inconsistency of the results. The aim of this study was to learn how the use of various bacteriological media as well as solvents may affect activity of lipopeptides and their cyclic analogs.

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“…Previous works have reported the inhibition of staphyloxanthin biosynthesis (and rendering S. aureus colourless) by inhibitors of squalene synthase (Song et al, 2009), statin drugs (Liu et al, 2008), indole derivatives (Lee et al, 2013) and rhodomyrtone, an antibiotic (Leejae, Hasap, & Voravuthikunchai, 2013). It should be noted that all these substances (except indole derivatives) are synthetic drugs, and, pose risk of dose limitation, toxicity issues and side effects.…”

Section: Effect Of Squalene On Ability Of S Aureus To Withstand Phagmentioning

confidence: 98%

Inhibition of virulence of Staphylococcus aureus – a food borne pathogen – by squalene, a functional lipid

Bindu

Bhaskar

2015

Journal of Functional Foods

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Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus by rhodomyrtone, a novel antibiotic candidate

Cited by 81 publications

References 55 publications

Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review

Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review

Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media

Inhibition of virulence of Staphylococcus aureus – a food borne pathogen – by squalene, a functional lipid

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