Inhibition of spontaneous and induced ovulation in rats by non-steroidal agents

Markó, M.; Flückiger, E.

doi:10.1007/bf01923674

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1976

1980

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Cited by 18 publications

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“…The experimental conditions were the same as described by Marko and Fliickiger [12], Ovulation-lest. Female rats (5 animals per dose) with regular 4-day cycles were injected s.c. during proestrus at noon with the test compound.…”

Section: Methodsmentioning

confidence: 99%

Role of Serotonin in the Regulation of Ovulation

Markó¹,

Flückiger²

1980

Neuroendocrinology

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Using two tests in intact adult rats, it has been found that a high positive correlation exists (p < 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, certain structural modifications induced similar activity changes in both tests. These pharmacological results support the view that serotonin plays an essential, apparently facilitatory role in the central mechanisms controlling ovulation in the rat.

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Section: Methodsmentioning

confidence: 99%