Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary

Sivakumar, Kirthiram K.; Stanley, Jone A.; Behlen, Jonathan; Wuri, Liga; Dutta, Sudipta; Wu, John Z.; Arosh, Joe A.; Banu, Sakhila K.

doi:10.1016/j.reprotox.2022.03.007

Cited by 8 publications

(6 citation statements)

References 70 publications

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“…also reported [55][56][57][58]. These events associate SIRT1 with the tumor suppressor p53, known to induce cell cycle arrest, and apoptosis while enhancing the DNA repair mechanism [122].…”

Section: Sirt1 Activation and Gc Healthmentioning

confidence: 79%

“…A protective action of SIRT1 on the viability of GCs and other cell types under oxidative stress-induced conditions was also reported [55–58]. These events associate SIRT1 with the tumor suppressor p53, known to induce cell cycle arrest, and apoptosis while enhancing the DNA repair mechanism [122].…”

Section: Introductionmentioning

confidence: 94%

“…Chromium (Cr) is another compound known to be toxic to germ and somatic ovarian cells. Sivakumar et al [58] reported that hexavalent chromium, Cr(VI), decreased the expression of SIRT1 and its ability to deacetylate p53. In an immortalized rat GC line, Cr(VI) inhibited the physical interaction between SIRT1 and acetyl-p53 and the SIRT1 inhibitor, EX-527, intensified Cr(VI)-induced effects, suggesting an association between SIRT1 and p53 in Cr(VI)induced cell apoptosis.…”

Section: Sirt1 Activation and Gc Healthmentioning

confidence: 99%

“…A number of in vitro studies also suggested that SIRT1 is involved in diverse ovarian functions including ovarian cell proliferation, apoptosis, folliculogenesis, oogenesis, and secretory activity [30,[47][48][49][50][51][52][53][54][55][56][57][58]. This review aims to provide state-of-the-art information on the expression and divergent roles of SIRT1 in GC function.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

Meidan

Szymańska

2023

Biology of Reproduction

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Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates non-histone substrates, e.g. tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ. Consequently, it regulates a wide range of physiological functions including cell cycle control, energy expenditure, oxidative stress response, apoptosis, and aging. SIRT1 is expressed in ovarian granulosa cells (GCs) of various species including humans at different stages of the reproductive cycle. The importance of SIRT1 in female reproduction is supported by the findings that SIRT1-knockout mice exhibit defects in reproductive tissue development. These mice were found to have a thin-walled uterus, small ovaries, with follicles present but no corpora lutea. This review aims to provide state-of-the-art information on SIRT1’s mode of action and its roles in human granulosa-lutein cells and GCs from other species where data is available. It also discusses the overlapping actions of SIRT1 and hCG on the production of critical GC-borne factors.

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Section: Sirt1 Activation and Gc Healthmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 94%

Section: Sirt1 Activation and Gc Healthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

Meidan

Szymańska

2023

Biology of Reproduction

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“…Class I HDACs are elevated during ovarian carcinogenesis and are independent prognostic factors for malignant ovarian tumors. Compared with normal ovarian tissues, SIRT1 is significantly elevated in malignant ovarian tumors [ 82 ], and it was described to induce chemoresistance and correlate with poor prognosis in OC [ 83 , 84 ].…”

Section: Targeting Epigenetic Modifiers In Gynecological Cancersmentioning

confidence: 99%

New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions

Zhang

Sheng

Sun

et al. 2023

Cancer Metastasis Rev

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Advanced and recurrent gynecological cancers lack effective treatment and have poor prognosis. Besides, there is urgent need for conservative treatment for fertility protection of young patients. Therefore, continued efforts are needed to further define underlying therapeutic targets and explore novel targeted strategies. Considerable advancements have been made with new insights into molecular mechanisms on cancer progression and breakthroughs in novel treatment strategies. Herein, we review the research that holds unique novelty and potential translational power to alter the current landscape of gynecological cancers and improve effective treatments. We outline the advent of promising therapies with their targeted biomolecules, including hormone receptor-targeted agents, inhibitors targeting epigenetic regulators, antiangiogenic agents, inhibitors of abnormal signaling pathways, poly (ADP-ribose) polymerase (PARP) inhibitors, agents targeting immune-suppressive regulators, and repurposed existing drugs. We particularly highlight clinical evidence and trace the ongoing clinical trials to investigate the translational value. Taken together, we conduct a thorough review on emerging agents for gynecological cancer treatment and further discuss their potential challenges and future opportunities.

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Ovarian Toxicology

Alapatt,

Flaws,

Rojas-Prado

et al. 2024

Reference Module in Biomedical Sciences

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Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary

Cited by 8 publications

References 70 publications

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions

Ovarian Toxicology

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