Inhibition of sexual maturation by a urinary pheromone in male prairie deer mice

Lawton, Angela; Whitsett, J. Mal

doi:10.1016/0018-506x(79)90052-7

Cited by 43 publications

(27 citation statements)

References 29 publications

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“…Male P. maniculatus exposed to aggressive females during development had reduced testes growth as adults (Whitsett and Miller, 1985). This effect is not likely to be due to chemical stimulation, as prior studies observed no effect of female urine exposure on male testes growth in P. maniculatus (Lawton and Whitsett, 1980). One hypothesis for the species difference in T in response to paired housing is that T responses to pair housing reflect variability in social systems.…”

Section: Discussionmentioning

confidence: 80%

Social and photoperiod effects on reproduction in five species of Peromyscus

Trainor

Martin

Greiwe

et al. 2006

General and Comparative Endocrinology

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At temperate latitudes, mammals and birds use changes in day length to time their reproductive activities to coincide with seasonal fluctuations in the environment. Close to the equator, however, conditions permissive of breeding do not track changes in day length as well, so other cues may be more important than photoperiod. In a variety of vertebrates, social interactions regulate breeding condition. We hypothesized that individuals of different species of Peromyscus mice found closer to the equator would respond more strongly to housing with an opposite sex conspecific than they would to photoperiod. To test this hypothesis, we compared the effects of long and short day lengths versus 8 days of pair housing with a female on reproductive tissue weights and testosterone (T) concentrations in five species of Peromyscus (P. aztecus, P. eremicus, P. maniculatus, P. melanophrys, and P. polionotus). After 13 weeks of short days (8L:16D), P. maniculatus, P. melanophrys, and P. polionotus significantly reduced relative testes mass compared to long day (16L: 8D) housed animals. Social housing, however, had no effect on tissue weights in any species. However, male P. polionotus paired with females for 8 days increased T concentrations compared to single-housed males, whereas paired P. maniculatus reduced T. These data suggest that mechanisms of photoperiodic and social regulation of reproductive function are mediated by different physiological mechanisms among closely-related species and that both phylogeny and environmental factors contribute to patterns of reproductive plasticity.

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Section: Discussionmentioning

confidence: 80%

Social and photoperiod effects on reproduction in five species of Peromyscus

Trainor

Martin

Greiwe

et al. 2006

General and Comparative Endocrinology

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“…Among rodents, perhaps the best example is the prairie deermouse, Peromyscus maniculatus bairdii, in which juvenile males are thought to be inhibited in their matu¬ ration by pheromones from adult males (Lawton & Whitsett, 1979). Subordinate males in social groups of marmoset monkeys have their sexual behaviour disrupted by dominant males, although they are occasionally seen copulating with the dominant breeding female.…”

Section: Discussionmentioning

confidence: 99%

Social suppression of reproduction in male naked mole-rats, Heterocephalus glaber

Faulkes¹,

Abbott²,

Jarvis³

1991

Reproduction

144

136

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Summary. To investigate possible anatomical and endocrine differences between breeding and non-breeding male naked mole-rats, 113 animals from 24 captive and 4 wild colonies were studied.While breeding males had larger reproductive tract masses compared to non-breeders relative to body mass (P < 0\m=.\01),spermatogenesis was active in all of the non-breeding males examined histologically (n = 9) and spermatozoa were present in the epididymides.Compared with non-breeders, breeding males had significantly higher urinary testosterone concentrations (mean \ m=+-\ s.e.m.: 23\m=.\8\ m=+-\ 2\m=.\3vs 5\m=.\2\ m=+-\1\m=.\4ng/mg Cr respectively; P < 0\m=.\001), and plasma LH (10\m=.\7\ m=+-\ 1\m=.\7vs 5\m=.\0\ m=+-\0\m=.\8 mi .u./ml respectively; P < 0\m=.\01). Single doses of 0\m=.\1,0\m=.\5 or 1\m=.\0 \g=m\g GnRH produced a significant rise in plasma LH concentrations 20 min after s.c. injection in breeding and non-breeding males at all doses (P < 0\m=.\001).However, there were differences in the magnitude of the LH response following administration of GnRH between breeding and non-breeding males, with non-breeding males showing a dose\p=n-\response and having lower plasma LH concentrations 20 min after a single injection of 0\ m=. \ 1 or 0\ m=. \ 5 \g=m\g(P < 0\m=.\05), but not 1\ m=. \ 0 \g=m\g, GnRH. This apparent lack of pituitary sensitivity of non-breeding males to single doses of exogenous GnRH was reversed by 4 consecutive injections of 0\m=.\5 \g=m\g GnRH at hourly intervals, suggesting that the reduced sensitivity may be the result of insufficient priming of the pituitary by endogenous GnRH.These results indicate that, despite the fact that non-breeding males were apparently producing mature gametes, clear endocrine deficiencies existed in male naked mole-rats.

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“…The surface of the penis was examined and micro¬ graphs were prepared at a magnification of 200. We also measured body weight, area of the androgen-dependent sebaceous gland (Lawton & Whitsett, 1979) (Oakberg, 1956) or that appeared to be a mature spermatozoon still attached to the luminal edge of the epithelium. Late spermatids were observed in tubules resembling cycle Stages I-VIII and XI-XII in mice (Oakberg, 1956;Clermont & Trott, 1969 fig.…”

Section: General Methodsmentioning

confidence: 99%