Inhibition of SARS–CoV–2 NSP–15 by Uridine–5′–Monophosphate Analogues Using QSAR Modelling, Molecular Dynamics Simulations, and Free Energy Landscape

Alshahrani, Mohammed Merae

doi:10.1016/j.jsps.2023.101914

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2024

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“…This prevented further transmission to family members, as the individual was advised to self-quarantine. In addition, the ability to target drugs to these conserved regions was validated with an independent recent study [ 15 ]. Early and quick detection could be crucial.…”

Section: Introductionmentioning

confidence: 99%

Comparative Bioinformatic Analysis Reveals Conserved Regions in SARS-CoV-2 Genome for RAPID Pandemic Response

Karpuj,

Shaytov,

Shemer-Avni

et al. 2024

IJMS

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In the face of the SARS-CoV-2 pandemic, characterized by the virus’s rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2, offering a strategic advantage in the fight against this and future pathogens. Our approach has enabled the creation of a diagnostic assay that is not only rapid, reliable, and cost-effective but also possesses a remarkable capacity to detect a wide array of current and prospective variants with unmatched precision. The significance of our findings lies in the demonstration that focusing on these conserved genomic sequences can significantly enhance our preparedness for and response to emerging infectious diseases. By providing a blueprint for the development of versatile diagnostic tools and therapeutics, this research paves the way for a more effective global pandemic response strategy.

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Section: Introductionmentioning

confidence: 99%