Inhibition of Rotavirus and Enterovirus Infections by Tea Extracts

Mukoyama, Atsushi; Ushijima, Hiroshi; Nishimura, Shigeyuki; Koike, Hinako; Toda, Masako; Hara, Yukihiko; Shimamura, Tadakatsu

doi:10.7883/yoken1952.44.181

Cited by 74 publications

(31 citation statements)

References 2 publications

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“…It may well be that EGCG interacts with AdV fiber protein to inhibit its binding to cellular GAGs (63). EGCG also inhibited the infectivity of rotavirus and enteroviruses, which was attributed to interference with virion adsorption to cells (64). However, the specific targets were not tested.…”

Section: Discussionmentioning

confidence: 99%

A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans

Colpitts

Schang

2014

J Virol

124

111

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Primary attachment to cellular glycans is a critical entry step for most human viruses. Some viruses, such as herpes simplex virus type 1 (HSV-1) and hepatitis C virus (HCV), bind to heparan sulfate, whereas others, such as influenza A virus (IAV), bind to sialic acid. Receptor mimetics that interfere with these interactions are active against viruses that bind to either heparan sulfate or to sialic acid. However, no molecule that inhibits the attachment of viruses in both groups has yet been identified. Epigallocatechin gallate (EGCG), a green tea catechin, is active against many unrelated viruses, including several that bind to heparan sulfate or to sialic acid. We sought to identify the basis for the broad-spectrum activity of EGCG. Here, we show that EGCG inhibits the infectivity of a diverse group of enveloped and nonenveloped human viruses. IMPORTANCEThis study shows that it is possible to develop a small molecule antiviral or microbicide active against the two largest groups of human viruses: those that bind to glycosaminoglycans and those that bind to sialoglycans. This group includes the vast majority of human viruses, including herpes simplex viruses, cytomegalovirus, influenza virus, poxvirus, hepatitis C virus, HIV, and many others.

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Section: Discussionmentioning

confidence: 99%

A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans

Colpitts

Schang

2014

J Virol

124

111

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“…Pre-and post-treatment of the cells themselves with epigallocatechin gallate produced significantly weaker effects. 48 In another study, epigallocatechin gallate (and theaflavin digallate) inhibited the infectivity of both influenza A virus and B virus in Madin-Darby canine kidney cells in culture. 49 Electron microscopic inspection revealed virus agglutination and inhibition of virus adsorption to the target cells.…”

Section: Antiviral Studiesmentioning

confidence: 97%

Chemoprotection: A review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituents

et al. 1997

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“…They have many physiological activities, such as antiviral, antioxidant and antibacterial activities. 17,18,[25][26][27] To determine the antiviral mechanism of theaflavins, we examined antiviral activity when FCV was treated with theaflavin monogallates (mixture of TF2A and 2B) and TF3 before contact with the cells. A mixture of theaflavins and virus were filtered to remove the remaining compounds from the test solution, and then cells were infected with the treated virus.…”

Section: Discovery Of Anti-calicivirus Compoundsmentioning

confidence: 99%

Antiviral effect of theaflavins against caliciviruses

et al. 2016

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Caliciviruses are contagious pathogens of humans and various animals. They are the most common cause of viral gastroenteritis in humans, and can cause lethal diseases in domestic animals such as cats, rabbits and immunocompromised mice. In this study, we conducted cytopathic effect-based screening of 2080 selected compounds from our in-house library to find antiviral compounds against three culturable caliciviruses: feline calicivirus, murine norovirus (MNV) and porcine sapovirus (PoSaV). We identified active six compounds, of which two compounds, both related to theaflavins, showed broad antiviral activities against all three caliciviruses; three compounds (abamectin, a mixture of avermectin B1a and B1b; avermectin B1a; and (− )-epigallocatechin gallate hydrate) were effective against PoSaV only; and a heterocyclic carboxamide derivative (BFTC) specifically inhibited MNV infectivity in cell cultures. Further studies of the antiviral mechanism and structure-activity relationship of theaflavins suggested the following: (1) theaflavins worked before the viral entry step; (2) the effect of theaflavins was time-and concentration-dependent; and (3) the hydroxyl groups of the benzocycloheptenone ring were probably important for the anti-calicivirus activity of theaflavins. Theaflavins could be used for the calicivirus research, and as potential disinfectants and antiviral reagents to prevent and control calicivirus infections in animals and humans.

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Inhibition of Rotavirus and Enterovirus Infections by Tea Extracts

Cited by 74 publications

References 2 publications

A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans

A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans

Chemoprotection: A review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituents

Antiviral effect of theaflavins against caliciviruses

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