Inhibition of reverse transcriptases by flavonoids

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

“…Quercetin affects bacteria by inhibiting the catalytic activity of DNA topoisomerase I and II (Constantinou et al, 1995;Hodec et al, 2002). Quercetin was also reported by Xu et al (2000) and Spedding et al (1989) to have inhibitory effects on HIV1-protease and reverse transcriptase.…”

S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

“…33) Moreover, it has been reported that flavonoids, including amentoflavone, inhibit DNA synthesis by the inhibition of reverse transcriptases in vitro. 34) Cell cycle analysis elucidated the S-phase arrest of the cell cycle by amentoflavone in C. albicans cells (Fig. 3).…”

Hispidulin And Other Constituents Of Scoparia dulcis Linn

“…Although inhibition was elicited at a concentration that also happened to be toxic to the cells, these results do not imply that hispidulin may not possess any type of anti-HIV property, particularly RT-inhibition, which is common with flavonoids (Spedding et al, 1989, De Clercq, 2001, Vlietinck et al, 1998. Efforts are therefore being made to have access to RTinhibition assay which was not readily available at the time of testing, to determine the RTinhibitory potential or otherwise of hispidulin.…”

“…However, its potential as an anti-HIV agent is yet to be reported. A variety of flavonoids have been shown to demonstrate anti-HIV activity, particularly the inhibition of different stages in the replication cycle of HIV (Spedding et al, 1989, De Clercq, 2001, Vlietinck et al, 1998. Among these are quercetin (3), myricetin (4), baicalein (5) and scutellarein (6), the latter being previously isolated from S. dulcis (Technical Data Report for Vassourinha).…”