Inhibition of RET signaling attenuates renal hypertrophic growth, proximal tubule dilation, and kidney damage in the 5/6Nx rat model of chronic kidney disease
Abstract:Progression of chronic kidney disease (CKD) involves compensatory hypertrophy of remaining nephrons leading to additional nephron loss. Understanding the precise mechanisms responsible for hypertrophy may help develop novel strategies to preserve renal function in people living with CKD. Our laboratory utilized the 5/6 nephrectomy (5/6Nx) rat model of renal insufficiency, where 2/3 of the left kidney and the entire right kidney was surgically excised in 10-week-old male Sprague Dawley rats. The remnant kidney … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.