Inhibition of Replication Fork Formation and Progression: Targeting the Replication Initiation and Primosomal Proteins
Holly M. Radford,
Casey J. Toft,
Alanna E. Sorenson
et al.
Abstract:Over 1.2 million deaths are attributed to multi-drug-resistant (MDR) bacteria each year. Persistence of MDR bacteria is primarily due to the molecular mechanisms that permit fast replication and rapid evolution. As many pathogens continue to build resistance genes, current antibiotic treatments are being rendered useless and the pool of reliable treatments for many MDR-associated diseases is thus shrinking at an alarming rate. In the development of novel antibiotics, DNA replication is still a largely underexp… Show more
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