2009
DOI: 10.1038/jcbfm.2009.257
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of Reactive Astrocytes with Fluorocitrate Retards Neurovascular Remodeling and Recovery after Focal Cerebral Ischemia in Mice

Abstract: Glial scarring is traditionally thought to be detrimental after stroke. But emerging studies now suggest that reactive astrocytes may also contribute to neurovascular remodeling. Here, we assessed the effects and mechanisms of metabolic inhibition of reactive astrocytes in a mouse model of stroke recovery. Five days after stroke onset, astrocytes were metabolically inhibited with fluorocitrate (FC, 1 nmol). Markers of reactive astrocytes (glial fibrillary acidic protein (GFAP), HMGB1), markers of neurovascular… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

4
90
0
1

Year Published

2010
2010
2022
2022

Publication Types

Select...
9
1

Relationship

2
8

Authors

Journals

citations
Cited by 140 publications
(95 citation statements)
references
References 43 publications
4
90
0
1
Order By: Relevance
“…Astrocytes are capable of secreting MMPs that disrupt the BBB, or releasing trophic factors that protect the BBB. During cerebral ischemia, pericapillary astrocyte end feet are the first cellular elements to swell [118], and MMPs and IL-1β released by astrocytes contribute to BBB disruption and vasogenic edema [119,120]. Astrocytes may also encourage angiogenesis [106] and regulate vascular tone [121], both processes crucial in restoring blood flow to infarcted tissues.…”
Section: Astrocytesmentioning
confidence: 99%
“…Astrocytes are capable of secreting MMPs that disrupt the BBB, or releasing trophic factors that protect the BBB. During cerebral ischemia, pericapillary astrocyte end feet are the first cellular elements to swell [118], and MMPs and IL-1β released by astrocytes contribute to BBB disruption and vasogenic edema [119,120]. Astrocytes may also encourage angiogenesis [106] and regulate vascular tone [121], both processes crucial in restoring blood flow to infarcted tissues.…”
Section: Astrocytesmentioning
confidence: 99%
“…It is well-known that stroke induces the activation of astrocytes to prevent immune cell invasion and to induce neurovascular remodeling. [32][33][34] Reactive astrocytes also are reported to show the progenitor markers Nestin, NG2, and Musashi-1 in the peri-infarct area. 25,35 Therefore, reactive astrocytes could play a key role in the recovery of function after stroke, although the relation between cell transplantation and reactive astrocytes is yet to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…However, emerging studies suggest that glia suppress the invasion of immune cells into the peri-infarct region [22], suggesting that they are not only protecting neurons in the acute phase of cerebral ischemia, but also promoting neurogensis and angiogenesis in the chronic phase [23,24]. Reactive astrocytes in peri-ischemic cortex may promote neurovascular remodeling, which becomes useful for the functional recovery after stroke [25]. IA plays an important role in the structural repair of brain tissue after cerebral ischemia.…”
Section: Discussionmentioning
confidence: 99%