Inhibition of Rat Mast Cell Degranulation and Histamine Release by Histamine-Rat Gammaglobulin Conjugate

Ishikawa, Takeru; Shimada, Tetsuo; Kessoku, Nobuko; Kiyoi, Masayoshi

doi:10.1159/000232287

Cited by 23 publications

(13 citation statements)

References 2 publications

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“…Ishikawa et al [8] reported that this inhibits his tamine release and degranulation of mast cells in rats. In addition, histamine inhibits histamine release from baso phils through H2 receptor on the surface of the target cells [9], Similarly, Tanizaki etal.…”

Section: Discussionmentioning

confidence: 97%

Cold Stimulation Test and Histamine Release in Primary Acquired Cold Urticaria

Capulong

Tomikawa²,

Tahara³

et al. 1997

Int Arch Allergy Immunol

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The patient was a 10-year-old boy who complained of urticaria upon exposure to cold air and after swimming in the pool. He also had seasonal asthma and wheezing after strenuous activities. To determine whether he had primary acquired cold urticaria, we performed a cold stimulation test twice. We likewise wanted to know whether a difference in response with regard to histamine release existed between blood samples taken from the challenged and the unchallenged sites. We obtained blood samples for histamine release initially at the site opposite the challenged forearm, and then on the same side on two separate occasions. We noted the appearance of constitutional signs and symptoms and correlated the time of their appearance with the result of histamine levels. The patient complained of pruritus and wheals appeared at the 5 minute in both tests. Results of plasma histamine release in the two measurements showed the highest releasability at 15 min. Our findings revealed that histamine is released systemically in response to cold stimulation regardless of the site where the blood sample was obtained.

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Section: Discussionmentioning

confidence: 97%

Cold Stimulation Test and Histamine Release in Primary Acquired Cold Urticaria

Capulong

Tomikawa²,

Tahara³

et al. 1997

Int Arch Allergy Immunol

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“…IVIg could also bind to histamine and block histamine activation of MC as seen in rats. 16 An additional trigger for MC activation includes T-cell activity and release of microparticles and cytokines. 17 IVIg increases regulatory T-cells which could reduce T-cell activity and thereby reduce MC activity.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

Weinstock¹,

Brook²,

Myers

et al. 2018

BMJ Case Reports

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A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial overgrowth (SIBO). A dramatic and sustained response was documented. The utility of IVIg in autoimmune neuromuscular diseases has been published, but clinical experience with POTS is relatively unknown and has not been reported in MCAS. As a short-acting mu-opioid antagonist, LDN paradoxically increases endorphins which then bind to regulatory T cells which regulate T-lymphocyte and B-lymphocyte production and this reduces cytokine and antibody production. IVIg is emerging as a promising therapy for POTS. Diagnosis and treatment of SIBO in POTS is a new concept and appears to play an important role.

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“…Also ASHIDA et al [29] recently reported that histamine at a concentration of 0,1 mM had no effect on cAMP levels in rat peritoneal mast cells. However, the finding by ISHIKAWA et al [30] that histamine or more specifically histamine-rat gammaglobulin conjugate inhibits rat mast cell degranulation, is at variance with this. A possibility exists that as in canine pulmonary airways [31], different rat strains have different numbers of H2-receptors on their mast cells.…”

Section: Speciesmentioning

confidence: 96%

A species comparison of the histamine H2-receptor on mast cells and basophils

Rising

Lewis

1982

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The histamine H2-agonist dimaprit was employed in experiments to investigate the role of H2-receptors in mediator release systems from the rat, guinea-pig and man. Whereas inhibition of histamine release by dimaprit was observed in all 3 species, this effect appeared not always to be related to H2-receptor occupancy. Although the data in general support previous evidence for the presence of H2-receptors on human basophils and guinea-pig mast cells, the use of dimaprit as a pure H2-agonist in these studies is questioned. No evidence for H2-receptors on rat mast cells was obtained.

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Inhibition of Rat Mast Cell Degranulation and Histamine Release by Histamine-Rat Gammaglobulin Conjugate

Cited by 23 publications

References 2 publications

Cold Stimulation Test and Histamine Release in Primary Acquired Cold Urticaria

Cold Stimulation Test and Histamine Release in Primary Acquired Cold Urticaria

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

A species comparison of the histamine H2-receptor on mast cells and basophils

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