Inhibition of Rat Intestinal Cl&lt;sup&gt;–&lt;/sup&gt; Secretion by 4,5-Dimethylresorcinol

Ogata, Norio; Shibata, Takashi

doi:10.1159/000080380

Cited by 8 publications

(6 citation statements)

References 60 publications

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“…Simple phenolics are some of the major components of wood creosote (Kuge et al, 2003;Morino et al, 2004;Ogata and Shibata, 2004). 4,5-Dimethylresorcinol has been shown to inhibit Cl − secretion (Ogata and Shibata, 2004). likelihood of interactions taking place.…”

Section: Discussionmentioning

confidence: 99%

Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function

2006

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Medicinal plants have been used as traditional treatments for numerous human diseases for thousands of years. Diarrhoeal diseases continue to be a major cause of morbidity and mortality throughout the world and there is renewed interest in the discovery of novel compounds that can be used to fight these diseases. Numerous studies have validated the traditional use of antidiarrhoeal medicinal plants by investigating the biological activity of extracts of such plants, which have antispasmodic effects, delay intestinal transit, suppress gut motility, stimulate water adsorption or reduce electrolyte secretion. Of the numerous phytochemicals (such as alkaloids, tannins, flavonoids and terpenes) present in active extracts, tannins and flavonoids are thought to be responsible for antidiarrhoeal activity by increasing colonic water and electrolyte reabsorption. Others act by inhibiting intestinal motility. As some of the active ingredients are potentially toxic, there is a need to evaluate the safety of plant preparations. A few clinical trials have evaluated the safety and tolerability of traditional and herbal medicine preparations used to treat diarrhoea and generally indicate that minimal side effects are observed. However, with the increased popularity of plant-derived and herbal medicines in Western society, the benefits and potential dangers of these medicines must be considered.

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Section: Discussionmentioning

confidence: 99%

Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function

2006

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“…In some countries WC, under the trade name of Seirogan, has long been used as an antidiarrheal medicine [2]. WC and its constituent compounds are known to suppress enterotoxin-induced intestinal fluid secretion via chloride channels [3][4][5] and to suppress smooth muscle contraction [6,7]. Indeed, one of the major constituents of WC, 4-ethylguaiacol, is known to possess the latter activity [8].…”

Section: Introductionmentioning

confidence: 99%

Absence of bactericidal activity of orally administered wood creosote on human intestinal bacterial flora

Ogata¹,

Miura²

2018

Integr Mol Med

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Wood creosote is a mixture of simple phenolic compounds that has long been used for over a century as an antidiarrheal medicine. While there are many pharmacological studies that explain its antidiarrheal effects, it has long been a matter of controversy whether the antidiarrheal activity of wood creosote is attributable to its putative bactericidal effect on the human intestinal bacterial flora. The objective of our study was to investigate the putative bactericidal effect of wood creosote in the human intestine when given in an ordinary therapeutic dose. To this end, we used an in vitro test to measure the minimal inhibitory concentration of wood creosote for various bacteria from the human gut. In addition, we also quantified the copy numbers of bacterial 16S ribosomal DNA in the feces of healthy human participants after administration of a therapeutic dose of wood creosote. We determined the minimal inhibitory concentration of wood creosote to be >128 µg/ml, a level far greater than that of commonly used antibacterial agents. Copy numbers of bacterial 16S ribosomal DNA in human feces after the administration of a therapeutic dose of wood creosote did not change significantly (p > 0.05) from that before dosing. Taken together, we conclude that wood creosote given at an ordinary therapeutic dose has no significant antibacterial effect in the human lower intestine where most of the intestinal bacterial flora resides. Thus, the antidiarrheal properties of wood creosote are not attributable to its effect on the intestinal bacterial flora, but rather to its other effects on the intestine.

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“…Moreover, wood creosote has been reported to directly inhibit the Cl − channel, cystic fibrosis transmembrane conductance regulator (CFTR) on the apical membrane. The inhibition of the Cl − channel induces an osmolality change, which suppresses water leakage [5]. Because Cl − channel hyper-activity is associated with different types of diarrhea [6], wood creosote may be effective against a wide range of diarrheal symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…It is a colorless or light-yellow liquid with a peculiar smell. Although wood creosote shows only a weak antibacterial effect, it shows no or very few adverse effects [4,5]. Therefore, wood creosote has been approved as a non-prescription drug.…”

Section: Introductionmentioning

confidence: 99%

Anti-Diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients

Takagi

Ito

Morino

et al. 2019

Reports

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Wood creosote, Seirogan, is a non-prescription drug used to treat diarrhea. However, reports of its clinical use are rare. Here, we report the efficacy of wood creosote (3 capsules daily) in alleviating diarrheal symptoms in 148 patients from 10 clinics in Osaka, Japan. Wood creosote was classified to be remarkably effective, effective, partially effective, or not effective on the basis of the degree of alleviation of diarrheal symptoms. The anti-diarrheal efficacy of wood creosote soft capsules did not differ between males and females. Younger patients (21–30 years) showed greater improvement in diarrhea symptoms than elderly patients (>61 years) did. Wood creosote soft capsules were remarkably effective (44 patients), effective (71 patients), and partially effective (13 patients) in alleviating diarrhea symptoms due to a variety of causes. To the best of our knowledge, this is the first report on the clinical effectiveness of wood creosote soft capsules in treating diarrhea.

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Inhibition of Rat Intestinal Cl<sup>–</sup> Secretion by 4,5-Dimethylresorcinol

Cited by 8 publications

References 60 publications

Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function

Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function

Absence of bactericidal activity of orally administered wood creosote on human intestinal bacterial flora

Anti-Diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients

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