Inhibition of protein synthesis in neoplastic cells by rhein

S, Castiglione; Paggi, Marco G.; Delpino, Andrea; Zeuli, Massimo; Floridi, Aristide

doi:10.1016/0006-2952(90)90481-y

Cited by 8 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports of the pharmacology of diacetyl rhein show that it can have a wide range of biological activity [12][13][14]. What is perhaps more significant is that using the protocol outlined in this paper, it is possible to determine the in vivo actions of various compounds on their ability to inhibit turnover.…”

Section: Inflamm Resmentioning

confidence: 94%

Anin vivo investigation of the effect of anthraquinones on the turnover of aggrecans in spontaneous osteoarthritis in the guinea pig

et al. 1995

View full text Add to dashboard Cite

We present details of a method which allows for the determination of chondroitin sulphate turnover in vivo using the guinea pig. Such methods have been utilised to examine the effects of diacetyl rhein, a compound with purported anti-osteoarthritic activity, and several related anthraquinone analogues on the turnover of chondroitin. Since the guinea pig develops spontaneous osteoarthritis, this may give useful information on the potential for such compounds to inhibit the progression of osteoarthritis. The results show that several of the anthraquinones are capable of reducing the turnover of chondroitin 4- but not 6-sulphate. This may indicate potential mechanisms for the breakdown of guinea pig cartilage aggrecans. We propose that these techniques could be useful for the screening of chemical agents with useful activity against osteoarthritis.

show abstract

Section: Inflamm Resmentioning

confidence: 94%

Anin vivo investigation of the effect of anthraquinones on the turnover of aggrecans in spontaneous osteoarthritis in the guinea pig

et al. 1995

View full text Add to dashboard Cite

show abstract

“…Chemical constituents of Cassia alata includes phenolics (chrysaphanol, emodin, rhein, aloe-emodin, kaempferol and their glycosides), fatty acids (palmitic, oleic, linoleic acids), terpenoids (␤-sitosterol, stigmasterol, campesterol) and anthraquinones (alatonal, alatinone) (Khare, 2007;Liu et al, 2009). Anthraquinones and flavonoids of Cassia alata are known to possess diverse range of biological activities (Castiglione et al, 1993(Castiglione et al, , 1990Borderie et al, 2001;Ackland et al, 2005;Chang et al, 2006;Bandyopadhyay et al, 2008;Choi and Ahn, 2008;Olszanecki et al, 2008;Aviello et al, 2009;Fernand et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition

Singh

Nadkarni²,

Vishwakarma

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…26 Furthermore, it has been reported that rhein affects energy metabolism by inducing a decrease in ATP production, ultimately leading to an impairment of protein synthesis. 27 It has been shown that rhein inhibits glucose uptake, 28 as well as oxidative phosphorylation, 26 and drastically lowers the adenylate energy charge. 27 It has also been demonstrated that rhein inhibits superoxide production and the activity of lysosomal enzyme.…”

Section: Introductionmentioning

confidence: 99%

“…27 It has been shown that rhein inhibits glucose uptake, 28 as well as oxidative phosphorylation, 26 and drastically lowers the adenylate energy charge. 27 It has also been demonstrated that rhein inhibits superoxide production and the activity of lysosomal enzyme. 29,30 Therefore, other investigators have pointed out that rhein may exact direct action on plasma and intracellular membranes.…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen affects arylamine N-acetyltransferase activity in Helicobacter pylori from peptic ulcer patients

et al. 1998

View full text Add to dashboard Cite

Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene and p-aminobenzoic acid were determined in the bacterium Helicobacter pylori collected from peptic ulcer patients. Cytosols or suspensions of H. pylori with or without specific concentrations of rhein co-treatment showed different percentages of 2-aminofluorene and p-aminobenzoic acid acetylation. The data indicate that there was decreased NAT activity associated with increased levels of rhein in H. pylori cytosols. Inhibition of growth studies from H. pylori demonstrated that rhein elicited dose-dependent bacteriostatic activity in H. pylori cultures: i.e. the greater the concentration of rhein, the greater the inhibition of growth to H. pylori. For the cytosol and intact bacteria examination, the apparent values of K m and V max were decreased after co-treatment with 40 M rhein. This report is the first demonstration of rhein inhibition of arylamine N-acetyltransferase activity and rhein inhibition of growth in the bacterium H. pylori.

show abstract

Inhibition of protein synthesis in neoplastic cells by rhein

Cited by 8 publications

References 27 publications

Anin vivo investigation of the effect of anthraquinones on the turnover of aggrecans in spontaneous osteoarthritis in the guinea pig

Anin vivo investigation of the effect of anthraquinones on the turnover of aggrecans in spontaneous osteoarthritis in the guinea pig

The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition

Ibuprofen affects arylamine N-acetyltransferase activity in Helicobacter pylori from peptic ulcer patients

Contact Info

Product

Resources

About