Inhibition of Premature Ventricular Contractions by Desflurane

Weiner, Menachem M.; Greco, Michael; Tsai, W. Kevin; Mittnacht, Alexander J.C.

doi:10.1053/j.jvca.2013.11.004

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Although both proarrhythmic and antiarrhythmic effects have been described, 79 most modern inhaled anesthetic agents seem to suppress ventricular arrhythmias. 85 Desflurane's sympathomimetic properties at greater doses and rapidly increasing concentrations, however, 86 have led to postulate arrhythmogenic effects in isolated cases. 64,81,82 In animal models, isoflurane reduced the incidence of ischemia, as well as reperfusioninduced arrhythmias, 83 and both desflurane and sevoflurane inhibited postinfarction ventricular arrhythmias.…”

Section: Anesthetic Drug Interactionmentioning

confidence: 99%

Ventricular Tachycardia Ablation

Mittnacht

Dukkipati

Mahajan³

2015

Anesthesia &Amp; Analgesia

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Percutaneous catheter ablation is being increasingly performed in patients with recurrent ventricular tachycardia (VT) unresponsive to medical treatment. Optimal management of patients requires careful consideration of the severity of the underlying cardiac disease, the anesthetic drug interactions, and the procedural technique during VT mapping and ablation. The goal is to choose an anesthetic technique that has the least effect on arrhythmogenicity, allowing reproducibility of the VT in the electrophysiology laboratory. Anesthetics can alter action potential and ventricular depolarization directly through their effects on ion channels and gap junctions, as well as indirectly via their effects on the autonomic nervous system. Furthermore, maintaining hemodynamic stability and monitoring for adequate end-organ perfusion are additional challenges. In this review, we provide a comprehensive update on the currently performed VT ablation procedures and their anesthetic considerations.

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