Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Hu, Quanyin; Liu, Hongjun; Archibong, Edikan; Chen, Qian; Ruan, Huitong; Ahn, Sarah; Dukhovlinova, Elena; Kang, Yang; Wen, Di; Dotti, Gianpietro; Gu, Zhen

doi:10.1038/s41551-021-00712-1

Cited by 211 publications

(153 citation statements)

References 40 publications

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“…11a–c ). 380 The encapsulated CAR-T cells displayed good survivability, proliferation, and bioactivity for targeting human chondroitin sulfate proteoglycan 4 that was selectively highly expressed in melanoma cells rather than healthy cells. After tumor excision, the inflammation at tumor site induced the activation of loaded platelet from hydrogel, and resulted in PD-L1 antibodies release from platelets via forming platelet-derived microparticles, and simultaneously resolved the immunosuppressive TME.…”

Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

“…Moreover, CAR-T cell delivery using hydrogels for tumor immunotherapy has also attracted increasing attentions. 380 , 381 …”

Section: In Vitro and In Vivo Potential Applications Of Hydrogelmentioning

confidence: 99%

“…a – c Preparation of a hyaluronic acid (HA)-based hydrogel that released CAR-T cells to target the human chondroitin sulfate proteoglycan 4 ( a ) and anti-PDL1-conjugated platelets for inhibiting post-surgery melanoma tumor recurrence ( b , c ). * p = 0.0486, *** p < 0.001 380 Copyright 2021, Springer nature. d – f Pufferfish-inspired ingestible hydrogel device ( d , e ) for long-term gastric retention and physiological monitoring like porcine gastric temperature ( f ).…”

Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

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Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao

Duan

Yan

et al. 2021

Sig Transduct Target Ther

420

256

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Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) and influence cell signaling cascades and fate. In the past few decades, a plethora of pioneering studies have been implemented to explore the cell–hydrogel matrix interactions and figure out the underlying mechanisms, paving the way to the lab-to-clinic translation of hydrogel-based therapies. In this review, we first introduced the physicochemical properties of hydrogels and their fabrication approaches concisely. Subsequently, the comprehensive description and deep discussion were elucidated, wherein the influences of different hydrogels properties on cell behaviors and cellular signaling events were highlighted. These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganization, gene expression, and further cell biology modulation (e.g., spreading, migration, proliferation, lineage commitment, etc.). Based on them, current in vitro and in vivo hydrogel applications that mainly covered diseases models, various cell delivery protocols for tissue regeneration and disease therapy, smart drug carrier, bioimaging, biosensor, and conductive wearable/implantable biodevices, etc. were further summarized and discussed. More significantly, the clinical translation potential and trials of hydrogels were presented, accompanied with which the remaining challenges and future perspectives in this field were emphasized. Collectively, the comprehensive and deep insights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate cellular processes, which are available for providing significant indications for future hydrogel design and serving for a broad range of biomedical applications.

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Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

“…Moreover, CAR-T cell delivery using hydrogels for tumor immunotherapy has also attracted increasing attentions. 380 , 381 …”

Section: In Vitro and In Vivo Potential Applications Of Hydrogelmentioning

confidence: 99%

Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao

Duan

Yan

et al. 2021

Sig Transduct Target Ther

420

256

View full text Add to dashboard Cite

show abstract

“…12a and b). 126 Once activated by the inflammatory microenvironment in the tumor resection cavity, the platelets could generate platelet-derived microparticles (PMPs) to release anti-PD-L1 antibodies. The hydrogel also contained PGLA nanoparticles encapsulating IL-15 to maintain the activation and proliferation of the loaded CAR-T cells.…”

Section: Functions Of Biomaterials In Adoptive Cell Therapymentioning

confidence: 99%

Recent advances in biomaterial-boosted adoptive cell therapy

Xue

Che

et al. 2022

Chem. Soc. Rev.

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“…Hu et al reported that a hyaluronic acid hydrogel carries PD-L1antibody (aPD-L1) which is grafted onto the platelet. When the hydrogel is injected into the tumor site, inflammation will initiate platelet activation and release aPD-L1, which achieves a controlled release (Hu et al, 2021).…”

Section: Degradablementioning

confidence: 99%

Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

Cui

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.

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Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Cited by 211 publications

References 40 publications

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Recent advances in biomaterial-boosted adoptive cell therapy

Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

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