Inhibition of plasma vasopressin after drinking in dehydrated humans

Geelen, G.; Keil, L. C.; Kravik, S. E.; Wade, C. E.; Thrasher, T. N.; Barnes, P.R.; Pyka, G.; Nesvig, C.; Greenleaf, J. E.

doi:10.1152/ajpregu.1984.247.6.r968

Cited by 85 publications

(73 citation statements)

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“…When dehydrated animals drink water, both responses are inhibited before systemic rehydration is evident. In dogs and human subjects, the early signal that inhibits thirst and VP secretion has been related to the volume of fluid consumed, apparently detected by oropharyngeal receptors that monitor the swallowing of liquids regardless of whether water, isotonic saline, or hypertonic saline solution is consumed (2,13,24,32). However, recent experiments indicate that early inhibition of VP secretion in rats is not mediated by oropharyngeal receptors (17,29) because plasma VP levels (pVP) were not affected either when dehydrated rats ingested isotonic saline or when water was consumed but drained from the stomach through an open gastric fistula (29).…”

mentioning

confidence: 99%

Inhibition of thirst when dehydrated rats drink water or saline

Hoffmann¹,

DenBleyker²,

Smith³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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The present experiments sought to identify the physiological signals that inhibit thirst when dehydrated rats drink water or NaCl solution. Rats were deprived of drinking fluid but not food overnight. When allowed to drink again, the dehydrated animals consumed water or saline (0.05 M, 0.10 M, 0.15 M, or 0.20 M NaCl solution) almost continuously for 5-8 min before stopping. The volumes consumed were similar regardless of which fluid they ingested, but blood analyses indicated that increased plasma osmolality and decreased plasma volume, or both, still remained when drinking terminated. These results suggest that the composition of the ingested fluid is less significant than its volume in providing an early signal that inhibits thirst and fluid consumption by dehydrated rats. Analyses of the gastrointestinal tracts revealed that the cumulative volume in the stomach and small intestine correlated highly with the amount consumed regardless of which fluid was ingested. These and other results suggest that the volume of fluid ingested by dehydrated rats is sensed by stretch receptors detecting distension of the stomach and small intestine, which provide an early inhibitory stimulus of thirst. dehydration; gastrointestinal distension; visceral osmoreceptors; water deprivation WATER DEPRIVATION ELICITS thirst and secretion of neurohypophyseal vasopressin (VP), the antidiuretic hormone, in rats and other animals (31). When dehydrated animals drink water, both responses are inhibited before systemic rehydration is evident. In dogs and human subjects, the early signal that inhibits thirst and VP secretion has been related to the volume of fluid consumed, apparently detected by oropharyngeal receptors that monitor the swallowing of liquids regardless of whether water, isotonic saline, or hypertonic saline solution is consumed (2,13,24,32). However, recent experiments indicate that early inhibition of VP secretion in rats is not mediated by oropharyngeal receptors (17, 29) because plasma VP levels (pVP) were not affected either when dehydrated rats ingested isotonic saline or when water was consumed but drained from the stomach through an open gastric fistula (29). In contrast, water ingested normally by thirsty rats initiated a rapid decline in pVP that began while systemic plasma Na ϩ concentrations (pNa) still were elevated (17, 29), suggesting that the inhibitory effect was not mediated by cerebral osmoreceptors but by a potent presystemic stimulus, related to the composition of ingested fluid, which might arise from osmoreceptors or Na ϩ receptors in the viscera (4, 19). Furthermore, the signal that terminated an initial bout of water consumption occurred a few minutes later, in association with a reduction of systemic pNa but continued plasma volume deficits (29). Because the intake of isotonic saline also ceased after similar volumes were consumed, without any associated change in pNa (29), these observations allow the hypothesis that thirst in rats is inhibited by signals related to the volume of ingested fluid rath...

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mentioning

confidence: 99%

Inhibition of thirst when dehydrated rats drink water or saline

Hoffmann¹,

DenBleyker²,

Smith³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…This was not significant for distilled water, 1.8% and 2.7% NaCl, but significant for 0.9% NaCl. In a similar work by Geelen, et al, (1984), the authors reported a decrease in thirst after drinking hypertonic saline. Obika and Mowoe (1977), and Rolls, et al, (1980) had reported an earlier observation of a fall in TP in normal euhydrate subjects when hypertonic and/or hypotonic fluid load was administered.…”

Section: Discussionmentioning

confidence: 79%

Thirst Perception And Drinking In Euhydrate And Dehydrate Human Subjects

Obika¹,

Idu²,

George³

et al. 2009

Nig. J. Phys Sci

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Summary: Studies on how the body senses the need to correct extracellular and intracellular volumes and ionic concentration changes is relatively scanty. The present studies were designed to determine the effect of oral distilled water (DW) and saline loads, gargling with DW and DW preload on thirst perception (TP) and drinking in euhydrate and dehydrated subjects. The subjects were healthy male volunteers between the ages of 17 and 35 years. Group A subjects were given DW or various concentrations of sodium chloride (NaCl) orally. Subjects in groups B, C and D were dehydrated for 18 hours before the experiment. Group B gargled 500ml of DW in divided volume of 50ml at five minutes interval over a period of 50 minutes. Group C gargled with DW and different concentrations of NaCl. Group D were preloaded with four volumes of DW before ad libitum DW intake. TP was rated using the Visual Analogue Scale. Results showed that in Group A, drinking DW reduced TP, suggesting that baseline TP in normal euhydrate subjects is slightly elevated. Drinking DW reduced TP more than drinking NaCl solutions. Gargling resulted in a gradual fall in TP. The decrease in TP was statistically significant after 30 minutes of gargling. Gargling with different concentrations of NaCl solutions resulted in significant reductions in TP in all the groups. There was a significant decrease in TP in the group preloaded with 1000ml of distilled water at 5 minutes of rehydration. At 20 minutes TP was abolished suggesting that approximately 1000ml of water was needed for the rehydration. These results show that baseline TP in euhydrates is elevated and that TP increases in dehydrated subjects. Gargling reduces TP, but did not abolish thirst. It is suggested that a fall in plasma osmolality due to drinking may be responsible for abolishing thirst.

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“…This effect preceded any change in plasma osmolality (Geelen, Keil, Kravik, Wade, Thrasher, Barnes, Pyka, Nesvig & Greenleaf, 1984;Thrasher, Nistal-Herrera, Keil & Ramsay, 1981). It has been suggested that this fall in plasma AVP is due to an oro-pharyngeal neuroendocrine reflex (Thrasher et al 1981).…”

Section: By M Chowdhury and Marianne Fillenz University Laboratory mentioning

confidence: 85%

Proceedings of the Physiological Society and the Societa Italiana Di Fisiologia, 11‐13 July 1985, Oxford Meeting: Poster Communications

1985

The Journal of Physiology

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Inhibition of plasma vasopressin after drinking in dehydrated humans

Cited by 85 publications

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Inhibition of thirst when dehydrated rats drink water or saline

Inhibition of thirst when dehydrated rats drink water or saline

Thirst Perception And Drinking In Euhydrate And Dehydrate Human Subjects

Proceedings of the Physiological Society and the Societa Italiana Di Fisiologia, 11‐13 July 1985, Oxford Meeting: Poster Communications

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