Inhibition of PI3K/mTOR/KATP channel blunts sodium thiosulphate preconditioning mediated cardioprotection against ischemia–reperfusion injury

Boovarahan, Sri Rahavi; Venkatasubramanian, Harini; Sharma, Nidhi; Venkatesh, S.; Prem, Priyanka N; Kurian, Gino A.

doi:10.1007/s12272-021-01339-1

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Na + –K + -ATPase and Ca 2+ –Mg 2+ -ATPase activities in the process of energy utilization were critical to energy utilization (Boovarahan et al. 2021 ). Obviously, the activity of Na + –K + -ATPase and Ca 2+ –Mg 2+ -ATPase in the skeletal muscle of EEP-treated fatigued rats increased dramatically compared to the fatigued rats, consistent with the biochemical indicators.…”

Section: Discussionmentioning

confidence: 99%

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

Zhang

Wang

et al. 2023

Pharmaceutical Biology

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Context Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia. Objective This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats. Materials and methods Sprague-Dawley rats were divided into control, model and EEP (ethanol extraction of P. ginseng roots) (50, 100 and 200 mg/kg) groups ( n = 8). The rats were subcutaneously handled with loaded swimming once daily for 26 days, except for the control group. The animals were intragastrically treated with EEP from the 15th day. On day 30, serum, liver and muscles were collected, and the PI3K/Akt/mTOR signalling pathway was evaluated. Results The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly ( p < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway. Conclusions Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue.

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Section: Discussionmentioning

confidence: 99%

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

Zhang

Wang

et al. 2023

Pharmaceutical Biology

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“… 14 , 40 For example, substantial infarct sparing effects were observed in both small and large animal models using different H 2 S sources. 15 , 24 , 40 , 41 , 42 , 43 , 44 …”

Section: Discussionmentioning

confidence: 99%

Sodium Thiosulfate in Acute Myocardial Infarction

de Koning,

van Dorp,

Assa

et al. 2023

JACC: Basic to Translational Science

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“…The authors further reported that STS pre-treatment preserved mitochondrial integrity, leading to protection against warm myocardial IRI [ 81 ]. However, such protection conferred by STS was abolished in the presence of PI3K/mTOR/K ATP inhibitors [ 82 ], suggesting that the mechanism underlying STS protection against myocardial IRI is at least partially via the PI3K/mTOR/K ATP pathway.…”

Section: Sodium Thiosulfate: a Clinically Viable H 2 ...mentioning

confidence: 99%

Pre-Treatment of Transplant Donors with Hydrogen Sulfide to Protect against Warm and Cold Ischemia-Reperfusion Injury in Kidney and Other Transplantable Solid Organs

McFarlane

Nelson

Dugbartey

et al. 2023

IJMS

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Ischemia-reperfusion injury (IRI), a pathological condition resulting from prolonged cessation and subsequent restoration of blood flow to a tissue, is an inevitable consequence of solid organ transplantation. Current organ preservation strategies, such as static cold storage (SCS), are aimed at reducing IRI. However, prolonged SCS exacerbates IRI. Recent research has examined pre-treatment approaches to more effectively attenuate IRI. Hydrogen sulfide (H2S), the third established member of a family of gaseous signaling molecules, has been shown to target the pathophysiology of IRI and thus appears to be a viable candidate that can overcome the transplant surgeon’s enemy. This review discusses pre-treatment of renal grafts and other transplantable organs with H2S to mitigate transplantation-induced IRI in animal models of transplantation. In addition, ethical principles of pre-treatment and potential applications of H2S pre-treatment in the prevention of other IRI-associated conditions are discussed.

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Inhibition of PI3K/mTOR/KATP channel blunts sodium thiosulphate preconditioning mediated cardioprotection against ischemia–reperfusion injury

Cited by 5 publications

References 24 publications

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

Sodium Thiosulfate in Acute Myocardial Infarction

Pre-Treatment of Transplant Donors with Hydrogen Sulfide to Protect against Warm and Cold Ischemia-Reperfusion Injury in Kidney and Other Transplantable Solid Organs

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