Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development

Guindi, Chantal; Khan, Farhan Ullah; Cloutier, Alexandre; Khongorzul, Puregmaa; Raki, Ahmed Aziz; Gaudreau, Simon; McDonald, Patrick P.; Gris, Denis; Amrani, Abdelaziz

doi:10.1016/j.trsl.2022.11.005

Cited by 2 publications

(2 citation statements)

References 67 publications

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“…As a transcription factor, the expression and activation of C/EBPβ is regulated by a number of upstream signal cascades, including Erk, GSK β, and p38 [ 18 , 19 ]. We therefore considered the possibility that the changes in C/EBPβ expression and activity that we have observed above might be regulated by other signals responding directly to the RF-EMR.…”

Section: Resultsmentioning

confidence: 99%

“…Our results indicated that 6 h of exposure to PW-RF EMR increased the expression and also specifically enhanced the transcriptional activity of C/EBPβ in oligodendroglial cells. As a transcription factor, the expression and activation of C/EBPβ is regulated by a number of upstream signal cascades, including Erk, GSK β, and p38 [18,19]. We therefore considered the possibility that the changes in C/EBPβ expression and activity that we have observed above might be regulated by other signals responding directly to the RF-EMR.…”

Section: Transcriptional Activity Of C/ebpβ Was Enhanced After Exposu...mentioning

confidence: 99%

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Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells

Huang

Zhao

Cai

et al. 2023

IJMS

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The rapid growth of wireless electronic devices has raised concerns about the harmful effects of leaked electromagnetic radiation (EMR) on human health. Even though numerous studies have been carried out to explore the biological effects of EMR, no clear conclusions have been drawn about the effect of radio frequency (RF) EMR on oligodendrocytes. To this end, we exposed oligodendroglia and three other types of brain cells to 2.4 GHz EMR for 6 or 48 h at an average input power of 1 W in either a continuous wave (CW-RF) or a pulse-modulated wave (PW-RF, 50 Hz pulse frequency, 1/3 duty cycle) pattern. RNA sequencing, RT-qPCR, and Western blot were used to examine the expression of C/EBPβ and its related genes. Multiple reaction monitoring (MRM) was used to examine the levels of expression of C/EBPβ-interacting proteins. Our results showed that PW-RF EMR significantly increased the mRNA level of C/EBPβ in oligodendroglia but not in other types of cells. In addition, the expression of three isoforms and several interacting proteins and targeted genes of C/EBPβ were markedly changed after 6-h PW-RF but not CW-RF. Our results indicated that RF EMR regulated the expression and functions of C/EBPβ in a waveform- and cell-type-dependent manner.

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Section: Resultsmentioning

confidence: 99%

Section: Transcriptional Activity Of C/ebpβ Was Enhanced After Exposu...mentioning

confidence: 99%

Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells

Huang

Zhao

Cai

et al. 2023

IJMS

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Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes

Ullah Khan,

Khongorzul,

Gris

et al. 2024

International Immunopharmacology

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Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development

Cited by 2 publications

References 67 publications

Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells

Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells

Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes

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