Inhibition of PGE<sub>2</sub>-EP2/EP4 signalingelicits anti-tumorimmunity through the suppression of mregDC-Treg axis ininflammatory tumor microenvironment
Abstract:In this work, we demonstrated that PGE2-EP2/EP4 signaling promoted active inflammation through NF-κBmediated upregulation of target proinflammatory and angiogenesis genes in myeloid cells and simultaneously induced immunosuppression through mregDC-mediated Ccl22 and Ccl17 production to facilitate Treg recruitment and activation in the tumor. We found that EP2/EP4 inhibition reduced NF-κB dependent gene expression, decreased Tregs infiltration and activation, and suppressed LLC1 tumor growth in mouse model. Mor… Show more
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