Inhibition of Pain and Pain-Related Brain Activity by Heterotopic Noxious Counter-Stimulation and Selective Attention in Chronic Non-Specific Low Back Pain

Ladouceur, Alexandra; Rustamov, Nabi; Dubois, Jacques; Tessier, Jessica; Lehmann, Alexandre; Descarreaux, Martin; Rainville, Pierre; Piché, Mathieu

doi:10.1016/j.neuroscience.2017.09.054

Cited by 16 publications

(16 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, although the main results are consistent with our hypotheses and with previous findings, the lack of group difference for some measures should be interpreted with caution and deserves further investigations. For example, the lack of NFR inhibition by HNCS in the control group may be due to a lack of power and is not consistent with our previous study that included 31 participants [27]. However, the NFR results are consistent with some of our previous studies, in which NFR was not significantly inhibited by HNCS in healthy volunteers [28,81].…”

Section: Limitationscontrasting

confidence: 75%

Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome

et al. 2020

Self Cite

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with chronic abdominal pain and altered pain processing. The aim of this study was to examine whether attentional processes contribute to altered pain inhibition processes in patients with IBS. Nine female patients with IBS and nine age-/sex-matched controls were included in a pain inhibition paradigm using counter-stimulation and distraction with electroencephalography. Patients with IBS showed no inhibition of pain-related brain activity by heterotopic noxious counter-stimulation (HNCS) or selective attention. In the control group, HNCS and selective attention decreased the N100, P260 and high-gamma oscillation power. In addition, pain-related high-gamma power in sensorimotor, anterior cingulate and left dorsolateral prefrontal cortex was decreased by HNCS and selective attention in the control group, but not in patients with IBS. These results indicate that the central pain inhibition deficit in IBS reflects interactions between several brain processes related to pain and attention.

show abstract

Section: Limitationscontrasting

confidence: 75%

Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Degreased skin over the retromalleolar path of the sural nerve was stimulated by a pair of custom-made surface electrodes (1 cm 2 ; 2 cm inter-electrode distance). The right and left RIII-reflex thresholds were determined separately using the staircase method including 4 series of stimuli of increasing and decreasing intensity, as in our previous studies 72,73 . Stimulus intensity was then adjusted individually to 60%, 120% or 140% of RIII-reflex threshold depending on the experimental condition.…”

Section: Methodsmentioning

confidence: 99%

“…Right RIII-reflex data were analyzed with Acknowledge 4.1.1 software. Raw EMG recordings were full-wave rectified and the resulting signal was used to quantify the amplitude of the RIII-reflex to each shock by extracting the integral value between 90–180 ms after the stimulus onset, as in our previous studies 72,73 . This amplitude was normalized within each subject for each shock using T scores, mean-centered at 50.…”

Section: Methodsmentioning

confidence: 99%

Integration of bilateral nociceptive inputs tunes spinal and cerebral responses

Rustamov

Northon

Tessier

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

Together with the nociceptive system, pain protects the body from tissue damage. For instance, when the RIII-reflex is evoked by sural nerve stimulation, nociceptive inputs activate flexor muscles and inhibit extensor muscles of the affected lower limb while producing the opposite effects on the contralateral muscles. But how do the spinal cord and brain integrate concurrent sensorimotor information originating from both limbs? This is critical for evoking coordinated responses to nociceptive stimuli, but has been overlooked. Here we show that the spinal cord integrates spinal inhibitory and descending facilitatory inputs during concurrent bilateral foot stimulation, resulting in facilitation of the RIII-reflex and bilateral flexion. In these conditions, high-gamma oscillation power was also increased in the dorsolateral prefrontal, anterior cingulate and sensorimotor cortex, in accordance with the involvement of these regions in cognitive, motor and pain regulation. We propose that the brain and spinal cord can fine-tune nociceptive and pain responses when nociceptive inputs arise from both lower limbs concurrently, in order to allow adaptable behavioural responses.

show abstract

“…Journal of Pain Research 2021:14 methodological modification allows for widening the scope of CPM applications to cases with altered or limited consciousness and vigilance, cognitive impairment, aphasic problems and dementia. The available electrophysiological alternatives quantifying the modulatory CPM effect on the test stimulus by assessing nociceptive flexion reflexes 23 or nociceptive brain potentials [24][25][26] are limited to very brief stimuli with a very immediate onset that do not mirror most clinical pain states. The use of facial responses allows application of clinically more relevant stimuli and responses.…”

Section: Dovepressmentioning

confidence: 99%

“…23 Moreover, in a few recent studies, nociceptive brain potentials were also used as an alternative method for CPM inhibition. [24][25][26] NFR and brain potentials can, however, only be elicited by very brief stimuli as produced by electrical current, short heat pulses and nasal gas puffs, that show little resemble to clinical pain states.…”

Section: Introductionmentioning

confidence: 99%

Conditioned Pain Modulation (CPM) Effects Captured in Facial Expressions

Kunz

Bunk

Karmann

et al. 2021

JPR

View full text Add to dashboard Cite

Purpose: Conditioned pain modulation (CPM) is most often assessed using self-report of pain. However, self-report of pain is not always available (eg in individuals with cognitive impairment) and is susceptible to report bias. In comparison, the facial expression of pain is more reflex-like and represents one of the most sensitive and specific non-verbal signals of pain. The aim of the present study was to investigate whether the facial expression of pain is sensitive enough to capture endogenous pain inhibition as elicited during CPM paradigms. Patients and Methods: In total, 26 female participants took part in this study. Facial and verbal responses to phasic heat pain were assessed once while participants immersed their hand in a hot water bath and once without additional stimulation. Facial responses were analyzed using the Facial Action Coding System (FACS). Verbal responses were assessed using a Numerical Rating Scale (NRS). Results: Pain-relevant facial responses as well as pain ratings to phasic heat pain were significantly reduced when participants simultaneously immersed their hand in a hot water bath compared to baseline. Thus, CPM effects could be demonstrated both on subjective as well as on facial responses. Moreover, CPM-induced changes in pain-relevant facial responses and in NRS ratings were significantly correlated. Conclusion: The present study shows that facial expressions of pain are sensitive enough to capture CPM effects. Given the proven clinical usefulness of assessing CPM, the parallel assessment of verbal and facial CPM effects might be a promising approach with wider scope of applications. Further research in other demographic healthy participant and clinical cohorts is warranted.

show abstract

Inhibition of Pain and Pain-Related Brain Activity by Heterotopic Noxious Counter-Stimulation and Selective Attention in Chronic Non-Specific Low Back Pain

Cited by 16 publications

References 53 publications

Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome

Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome

Integration of bilateral nociceptive inputs tunes spinal and cerebral responses

Conditioned Pain Modulation (CPM) Effects Captured in Facial Expressions

Contact Info

Product

Resources

About