“…There is a big effort being made to model neurodevelopmental disorders such as microcephaly (Gabriel et al, 2016;Lancaster et al, 2013), macrocephaly (Li, Muffat, et al, 2017), lissencephaly (Bershteyn et al, 2017;Iefremova et al, 2017;Li, Muffat, et al, 2017), periventricular heterotopia (Klaus et al, 2019;O'Neill, Kyrousi, Einsiedler, et al, 2018;O'Neill, Kyrousi, Klaus, et al, 2018) and autism spectrum disorder (Mariani et al, 2015). Other types of diseases, which were already modeled using brain organoids are genetic, mental and neurodegenerative disorders such as schizophrenia (Ye et al, 2017), Sandhoff disease (Allende et al, 2018), Alzheimer (Raja et al, 2016), frontotemporal dementia (Seo et al, 2017) and Rett-syndrome (Mellios et al, 2018). Finally organoids are an ideal model for drug development or viral transduction and in particular organoids have been used to investigate the function of Zika virus on human brain development (Dang et al, 2016;Garcez et al, 2016;Qian et al, 2017).…”