Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice

Wang, Lu; Pei, Juan-Hui; Jia, Jianxin; Wang, Jing; Song, Wei; Fang, Xin; Cai, Zhen; Huo, Dong-Sheng; Wang, He; Yang, Zhenhua

doi:10.1080/15287394.2019.1683988

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…Previous studies have found that testosterone has the effect of antioxidative stress [ 63 , 64 ]. Wang et al [ 65 ] reported that testosterone supplementation significantly decreased the concentration of MDA in the hippocampus, which explains the higher MDA levels observed in female controls when compared to male healthy controls. Second, in regards to the patients with schizophrenia, increased dopamine in the nigra-striatal pathway is considered to be a driving force of psychosis [ 66 , 67 ], and the effectiveness of antipsychotics that block the dopamine D2 receptor in relieving hallucinations and delusions is well established [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Zhu

Liu

Guo

et al. 2021

J Neuroinflammation

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Background Increasing evidence indicates that dysregulated TNF-α and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. Additionally, previous evidence has demonstrated sex differences in many aspects of schizophrenia including clinical characteristics, cytokines, and OxS markers. However, to the best of our knowledge, there is no study investigating sex differences in the association between TNF-α, the OxS system, and their interaction with clinical symptoms in schizophrenia patients, especially in first-episode drug-naïve (FEDN) patients. Methods A total of 119 FEDN schizophrenia patients and 135 healthy controls were recruited for this study. Serum TNF-α, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA) were measured. The Positive and Negative Syndrome Scale (PANSS) was applied to evaluate psychotic symptoms. Two-way ANOVA, partial correlation analysis, and multivariate regression analysis were performed. Results A sex difference in MDA levels was demonstrated only in healthy controls (F = 7.06, pBonferroni = 0.045) and not seen in patients. Furthermore, only male patients had higher MDA levels than male controls (F = 8.19, pBonferroni = 0.03). Additionally, sex differences were observed in the association of TNF-α and MDA levels with psychotic symptoms (all pBonferroni < 0.05). The interaction of TNF-α and MDA was only associated with general psychopathology symptom in male patients (B = − 0.07, p = 0.02). Conclusion Our results demonstrate the sex difference in the relationship between TNF-α, MDA, and their interaction with psychopathological symptoms of patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Zhu

Liu

Guo

et al. 2021

J Neuroinflammation

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“…Previous studies have found that testosterone has the effect of antioxidative stress [39][40]. Wang et al [41] reported that testosterone supplementation signi cantly decreased the concentration of MDA in the hippocampus, which explains the higher MDA levels observed in female controls when compared to male healthy controls. Second, in regards to the patients with schizophrenia, increased dopamine in the nigra-striatal pathway is considered to be a driving force of psychosis [42][43], and the effectiveness of antipsychotics that block the dopamine D2 receptor in relieving hallucinations and delusions is well established [44].…”

Section: Discussionmentioning

confidence: 95%

Sex Difference in the Interrelationship Between TNF-α and Oxidative Stress Status in First-episode Drug-naïve Schizophrenia

Zhu

Liu

Rippe

et al. 2020

Preprint

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BackgroundIncreasing evidence indicates that dysregulated TNF-α and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. Additionally, previous evidence has demonstrated sex differences in many aspects of schizophrenia including clinical characteristics, cytokines and OxS markers. However, to the best of our knowledge, there is no study investigating sex differences in the association between TNF-α, the OxS system, and their interaction with clinical symptoms in schizophrenia patients, especially in first-episode drug-naïve (FEDN) patients. MethodsA total of 119 FEDN schizophrenia patients and 135 healthy controls were recruited for this study. Serum TNF-α, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA) were measured. The Positive and Negative Syndrome Scale (PANSS) was applied to evaluate psychotic symptoms. Two-way ANOVA, partial correlation analysis and multivariate regression analysis were performed. ResultsA sex difference in MDA levels was demonstrated only in healthy controls (F = 7.06, p Bonferroni = 0.045) and not seen in patients. Furthermore, only male patients had higher MDA levels than male controls (F = 8.19, p Bonferroni = 0.03). Additionally, sex differences were observed in the association of TNF-α and MDA levels with psychotic symptoms (all pBonferroni<0.05). The interaction of TNF-α and MDA was only associated with general psychopathology symptom in male patients (B = -0.07, p = 0.02). ConclusionOur results demonstrate the sex difference in the relationship between TNF-α, MDA, and their interaction with psychopathological symptoms of patients with schizophrenia.

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“…However, there are also reports that T has an antioxidant effect on the human prostate gland [ 91 ] and the nervous system in rats [ 16 , 92 ]. Low T levels increase oxidative stress [ 93 ] and lead to a redox imbalance [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Sperm Dysfunction in the Testes and Epididymides due to Overweight and Obesity Is Not Caused by Oxidative Stress

Ruiz-Valderrama

Posadas-Rodríguez

Bonilla-Jaime

et al. 2022

International Journal of Endocrinology

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Obesity is a condition that has been linked to male infertility. The current hypothesis regarding the cause of infertility is that sperm are highly sensitive to reactive oxygen species (ROS) during spermatogenesis in the testes and transit through the epididymides, so the increase in ROS brought on by obesity could cause oxidative stress. The aim of this study was to evaluate whether the activity of the enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) is capable of counteracting oxidative stress in sperm. The male Wistar rat was used as an overweight and obesity model, and analysis of fertility in these groups was carried out including the control group. Serum testosterone levels were determined, and the scrotal fat, testes, and epididymides were extracted. The epididymides were separated ini0 3 principal parts (caput, corpus, and cauda) before evaluating sperm viability, sperm morphology, damage to desoxyribonucleic acid of the sperm, and ROS production. The protein content and specific activity of the three enzymes mentioned above were evaluated. Results showed a gain in body weight and scrotal fat in the overweight and obese groups with decreased parameters for serum testosterone levels and sperm viability and morphology. Fertility was not greatly affected and no DNA integrity damage was found, although ROS in the epididymal sperm increased markedly and Raman spectroscopy showed a disulfide bridge collapse associated with DNA. The specific activities of CAT and GPX increased in the overweight and obesity groups, but those of SOD did not change. The amounts of proteins in the testes and epididymides decreased. These findings confirm that overweight and obesity decrease concentrations of free testosterone and seem to decrease protein content, causing poor sperm quality. Implications. An increase in scrotal fat in these conditions fosters an increase of ROS, but the increase of GPX and CAT activity seems to avoid oxidative stress increase in the sperm without damaging your DNA.

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Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice

Cited by 13 publications

References 34 publications

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Sex Difference in the Interrelationship Between TNF-α and Oxidative Stress Status in First-episode Drug-naïve Schizophrenia

Sperm Dysfunction in the Testes and Epididymides due to Overweight and Obesity Is Not Caused by Oxidative Stress

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Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice

Cited by 13 publications

References 34 publications

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Sex Difference in the Interrelationship Between TNF-α&nbsp;and Oxidative Stress Status in First-episode Drug-naïve Schizophrenia

Sperm Dysfunction in the Testes and Epididymides due to Overweight and Obesity Is Not Caused by Oxidative Stress

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Sex Difference in the Interrelationship Between TNF-α and Oxidative Stress Status in First-episode Drug-naïve Schizophrenia