Inhibition of ovulation by tyrosine kinase inhibitors in the in vitro perfused rat ovary

Matousek, M; Mikuni, M; Mitsube, Kenrokuro; Yoshida, Mitsuhiko; Brännström, Mats

doi:10.1530/jrf.0.1170379

Cited by 8 publications

(7 citation statements)

References 7 publications

(9 reference statements)

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“…Action TKs blockers demonstrated, that TKs can inhibit progesterone, estradiol, but not IGF-I and PGF-2 alpha output by mammalian granulosa nad whole ovarian follicles (Makarevich et al, 1997), although other studies did not confirm the involvement of TK signaling pathways in control of synthesis of mammalian ovarian steroids, plasminogen activator or prostaglandins (Matousek et al, 1999). In chicken ovaries, TKs was shown to suppress release of estradiol and argininevasotocin, but not progesterone and testosteron (Sirotkin and Grossmann, 2003).…”

Section: Protein Kinases Control Release Of Hormones By Ovarian Cellsmentioning

confidence: 95%

“…4). Effect of pharmacological activators or blockers of PKs showed, that PKA, PKG, MAPKs, PI3K/Akt, CDKs, TKs, and ALK can both promote (in some cases also suppress) ovarian granulosa cell proliferation (Makarevich et al, , 2004bTamura et al, 2004;Sirotkin andGrossmann, 2003, 2006;Wang and Tsang, 2007), although the ability of TK-dependent intracellular signaling to stimulate ovarian folliculogenesis and ovulation is reported too (Matousek et al, 1999). The cAMP/PKAdependent intracellular mechanisms can either inhibit (Peluso, 2006;Graves and Lawrence, 1996;Hsueh et al, 1996;Hillier and Tetsuka, 1997), stimulate (Cheadle et al, 2008;Viegas et al, 2008) or not influence (Dupont et al, 2008) follicular cell proliferation, but other PKs are involved predominantly in promotion of ovarian cell cycle.…”

Section: Protein Kinases Control Ovarian Cell Proliferationmentioning

confidence: 99%

“…Regulators of PKA, PKG, MAPKs, PI3K, Akt, CDKs, TKs, and ALK affecting ovarian follicular cell proliferation (Peluso, 2006;Graves and Lawrence, 1996;Hsueh et al, 1996;Hillier and Tetsuka, 1997;Matousek et al, 1999;Makarevich et al, 2002Makarevich et al, , 2004bTamura et al, 2004;Sirotkin andGrossmann, 2003, 2006;Wang and Tsang, 2007;Dupont et al, 2008;Cheadle et al, 2008;Viegas et al, 2008) can be used for stimulation of ovarian folliculogenesis, increase in number of ovulations and, perhaps, for control of hypogonadism, PCOS and other ovarian disorders associated with impaired follicular growth.…”

Section: Interrelationships Between Different Protein Kinases In Thementioning

confidence: 99%

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Protein kinases and ovarian functions

Sirotkin

Makarevich

Grosmann³

2010

Journal Cellular Physiology

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The present focus survey represents a short review of current knowledge concerning involvement of protein kinases in control of basic ovarian functions. Ovarian cells produce a number of protein kinases, whose expression depends on type of cells, their state and action of hormones and other protein kinases. A number of protein kinases are involved in control of ovarian cell proliferation, apoptosis, oocyte maturation, hormone release, reception and response to hormones, as well as in mediating action of hormones on these ovarian functions. Complexity of interrelationships between different protein kinase-dependent signaling pathways occurs. Protein kinases and their regulators could be used for characterization, prediction and control of ovarian folliculogenesis and atresia, Corpus luteum functions, oocyte maturation, fertility, release of hormones, response of ovarian structures to hormonal regulators, as well as for treatment of some reproductive disorders. The present data demonstrate importance of protein kinases in control of basic ovarian function and potential usage of protein kinases for characterization, prediction and control of these functions.

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Section: Protein Kinases Control Release Of Hormones By Ovarian Cellsmentioning

confidence: 95%

Section: Protein Kinases Control Ovarian Cell Proliferationmentioning

confidence: 99%

Section: Interrelationships Between Different Protein Kinases In Thementioning

confidence: 99%

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Protein kinases and ovarian functions

Sirotkin

Makarevich

Grosmann³

2010

Journal Cellular Physiology

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“…Different caspase inhibitors (dissolved in Me 2 SO) diluted in 0.15 M NaCl solution or vehicle solution for the respective inhibitors (15 g/ ovary) were injected into the ovarian bursal cavity in a volume of 60 l. Only animals with the swelling of bursa and no visible leakage of the injected fluids were included in the study (n ϭ 3 rats/treatment group). The intrabursal route of administration has been utilized in various in vivo studies to deliver different drugs to the ovary (31)(32)(33). After the completion of the injection procedure, ovaries were returned to the abdominal cavity and the abdominal wall was sutured with absorbable suture and the skin with the surgical clips.…”

Section: A Pgf 2␣ -Induced Luteal Tissue Apoptosis In the Buffalo Comentioning

confidence: 99%

Prostaglandin F2α-mediated Activation of Apoptotic Signaling Cascades in the Corpus Luteum during Apoptosis

Yadav¹,

Lakshmi

Medhamurthy

2005

Journal of Biological Chemistry

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Prostaglandin F 2␣ (PGF 2␣ ) acting via a G protein-coupled receptor has been shown to induce apoptosis in the corpus luteum of many species. Studies were carried out to characterize changes in the apoptotic signaling cascade(s) culminating in luteal tissue apoptosis during PGF 2␣ -induced luteolysis in the bovine species in which initiation of apoptosis was demonstrable at 18 h after exogenous PGF 2␣ treatment. An analysis of intrinsic arm of apoptotic signaling cascade elements revealed that PGF 2␣ injection triggered increased ratio of Bax to Bcl-2 in the luteal tissue as early as 4 h posttreatment that remained elevated until 18 h. This increase was associated with the elevation in the active caspase-9 and -3 protein levels and activity (p < 0.05) at 4 -12 h, but a spurt in the activity was seen only at 18 h posttreatment that could not be accounted for by the changes in the Bax/Bcl-2 ratio or changes in translocation of Bax to mitochondria. Examination of luteal tissue for FasL/Fas death receptor cascade revealed increased expression of FasL and Fas at 18 h accompanied by a significant (p < 0.05) induction in the caspase-8 activity and truncated Bid levels. Furthermore, intrabursal administration of specific caspase inhibitors, downstream to the extrinsic and intrinsic apoptotic signaling cascades, in a pseudopregnant rat model revealed a greater importance of extrinsic apoptotic signaling cascade in mediating luteal tissue apoptosis during PGF 2␣ treatment.

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“…In recent years, evidence has begun to accumulate that, NGF and its receptors trkA and p75 have important roles in sexual development [8], folliclular development and ovulation [14][15][16]. In mammals, throughout the functional lifespan of the ovary, the process of follicle recruitment, follicular development and ovulation, secretion of steroid hormones is cyclic a n d d e p e n d s o n t h e c y c l i c s e c r e t i o n o f gonadotropins from the pituitary [17].…”

Section: T O D a T E B E S I D E S N G F B R A I N -D E R I V E Dmentioning

confidence: 99%

Expression of Nerve Growth Factor (NGF), and Its Receptors trkA and p75 in Ovaries of the Cyclic Golden Hamster (<i>Mesocricetus auratus</i>) and the Regulation of Their Production by Luteinizing Hormone

Shi

Wei

Watanabe

et al. 2004

Journal of Reproduction and Development

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Abstract. In the present study, changes in localization of nerve growth factor (NGF) and its receptors, trkA and p75 in the ovary were investigated during the estrous cycle of the golden hamster. The effect of LH surge on changes in localization of NGF, trkA and p75 in the ovary was also investigated. NGF and its receptors trkA and p75 were localized in oocytes, granulosa cells and theca cells of various stages of follicles throughout the estrous cycle. NGF and its two receptors were also present in numerous interstitial cells and luteal cells. The number of interstitial cells staining positively for NGF and its two receptors was greater in ovaries of day 1 (day 1=day of ovulation) than the other days during the estrous cycle. Treatment with the antiserum against luteinizing hormone releasing hormone (LHRH-AS) at 1100 h on day 4 completely blocked ovulation. There were few positive reactions for NGF and its two receptors in interstitial cells 24 hr after LHRH-AS injection. The effect of LHRH-AS treatment was blocked by a single injection of 10 IU human chorionic gonadotropin. The distinct widespread distribution of NGF and its two receptors in the ovary of golden hamsters suggest that NGF may be an important growth factor for regulation of ovarian function. Furthermore, the LH surge may be an important factor for inducing production of NGF and its two receptors in interstitial cells of the cyclic golden hamster. Key words: Estrous cycle, Golden hamster, Ovary, Nerve growth factor, TrkA, P75 (J. Reprod. Dev. 50: [605][606][607][608][609][610][611] 2004) he neurotrophins (NTs) are target-derived growth factor required for differentiation, survival and development of discrete neuronal populations in the central and peripheral nervous systems [1,2]. It is also believed that NTs not only have an effect on the nervous system, but also play an important role in regulating the development of non-neuronal cells, including cellular subsets of the immune, cardiovascular and endocrine systems [3][4][5]. The mammalian ovary is innervated by both sympathetic and sensory neurons of the peripheral nervous system [6]. It has been demonstrated that the survival and differentiation of the neurons i n n e r v a t i n g t h e o v a r y a r e s u p p o r t e d b y neurotrophic substances produced in the gland [7,8 ] . T o d a t e , b e s i d e s N G F , b r a i n -d e r i v e d

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Inhibition of ovulation by tyrosine kinase inhibitors in the in vitro perfused rat ovary

Cited by 8 publications

References 7 publications

Protein kinases and ovarian functions

Protein kinases and ovarian functions

Prostaglandin F2α-mediated Activation of Apoptotic Signaling Cascades in the Corpus Luteum during Apoptosis

Expression of Nerve Growth Factor (NGF), and Its Receptors trkA and p75 in Ovaries of the Cyclic Golden Hamster (<i>Mesocricetus auratus</i>) and the Regulation of Their Production by Luteinizing Hormone

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