Inhibition of Osteoclast Differentiation by Gold Nanoparticles Functionalized with Cyclodextrin Curcumin Complexes

Hee, Sun; Ko, Wan‐Kyu; Moon, Hojin; Kim, Hanjun; Lee, Sang Jin; Lee, Jung Bok; Bae, Min Soo; Yi, Jin-Kyu; Hwang, Yu‐Shik; Bang, Jae Beum; Kim, Eun-Cheol; Kwon, Il Keun

doi:10.1021/nn504329u

Cited by 114 publications

(91 citation statements)

References 48 publications

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“…It was found that all components showed no significant cytotoxic effects up to 48 h. On the contrary, GNPs and RGNPs exhibited a slight positive effect on ADSCs proliferation where the cell viability increased at a dose-dependent manner after 48 h. It was reported that the surface ligand of the GNPs have an important influence on the cytotoxicity. 29–31, 37 In this study, we used two kinds of GNPs covered with citrate and RGD, and they showed no cytotoxicity and even more enhanced cell proliferation. Therefore, this result indicates that the prepared RGNPs could be useful as a biocompatible osteo-inductive agent.…”

Section: Resultsmentioning

confidence: 99%

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

et al. 2017

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Three-dimensional (3D) functional constructs with biomimetic mechanical and chemical properties are ideal for various regenerative medicine applications. Within a 3D fabricated construct these properties are intrinsic characteristics of the materials and fabrication method. In this respect, the current use of hydrogels for musculoskeletal tissue repair are not perfect due to the lack of suitable mechanical properties, as well as the high biomimetic requirement for success. To overcome this limitation, we developed a novel functionalized hydrogel with bioactive gold nanoparticles (GNPs) and reinforcing 3D printed microstructure via fused deposition modeling (FDM) for bone tissue regeneration. We used the biodegradable thermoplastic polylactic acid (PLA) as the 3D printed microstructure in combination with photo-curable gelatin hydrogels as the encapsulation matrix for the incorporation of cyclicRGD conjugated GNPs (RGNP), and investigated their mechanical properties. In addition, human adipose-derived stem cells (ADSCs) were encapsulated within the gelatin hydrogel and examined for viability, morphology, and osteogenic differentiation in vitro. The results showed that the stiffness of the composite hydrogel with reinforcing 3D printed microstructure can be readily modulated to simulate the stiffness of the human mandibular condyle. ADSCs encapsulated in the composite structures remained viable within the hydrogel and showed excellent spreading on the 3D printed PLA microstructure. More importantly, osteogenic differentiation with incorporated RGNP promoted significantly higher gene expression of osteogenic specific factors. Therefore, reinforced composite hydrogels are suitable for stem cell differentiation control and bone tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

et al. 2017

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“…GNPs show potential for bone-targeted drug delivery because of their ease of functionalization with drugs, targeting moieties, and polymers on gold-thiol bonds [48], as well as their intrinsic ability to upregulate OB activity [49] and downregulate OC differentiation [50,51]. In particular, GNPs can downregulate OC formation by inhibiting the function of the osteoclastogenesis promoter, RANK ligand (RANKL), and by reducing reactive oxygen species (ROS) levels [52].…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

“…To improve CUR delivery, Heo et al . developed GNPs functionalized with β-cyclodextrin (βCD), which can stabilize CUR through the formation of βCD-CUR inclusion complexes (Figure 2b) [50]. The in vitro results demonstrated that the GNP-βCD-CUR could inhibit the OC differentiation of bone marrow-derived macrophages (BMM).…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

“…The in vitro results demonstrated that the GNP-βCD-CUR could inhibit the OC differentiation of bone marrow-derived macrophages (BMM). Furthermore, in an ovariectomy-induced (OVX-induced) OP mouse, the application of GNP-βCD-CUR prevented bone loss and increased bone dimensions in trabecular bone, because of the improved intracellular delivery of GNP-loaded CUR [50]. …”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

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Development of nanomaterials for bone-targeted drug delivery

Cheng

Chawla

Yang

et al. 2017

Drug Discovery Today

116

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Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.

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“…Hybrid nanoparticles, prepared by desolvation, encapsulated curcumin with >96 % effi ciency and increased the stability of curcumin 6.7 times. Cyclodextrins were also used to improve the water solubility and stability of curcumin through the formation of inclusion complexes [ 13 ]. The complexes were tested as such and also after functionalizing gold nanoparticles.…”

Section: Phenolic Compounds From Plant Sources Delivered As Nanopartimentioning

confidence: 99%

Bionanomaterials from Plant Sources

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

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At the present an unprecedented interest in herbal healing is appearing everywhere. The Western world started to compare allopathic remedies (with many side effects) to the traditional ones and to acknowledge the latter as safer alternatives. In spite of their advantages, applications are slow to materialize, with poor solubility and low bioavailability being the main reasons. Natural products such as curcumin, hop extracts, essential oils are example of species with demonstrated biological activity but few applications due to unsatisfactory bioavailability correlated with low water solubility. Natural products with strong antioxidant effect, like polyphenols in teas, for example, are not widely used because of their sensitivity to oxidation (during processing and storage).Nanotechnology offers a huge promise for these compounds. The disadvantages mentioned disappear upon encapsulating them in nanosized carriers with appropriate chemistry. An added bonus thereof is the possibility of controlled delivery. Phenolic Compounds from Plant Sources Delivered as NanoparticlesPolyphenols are chemical structures in which there is at least one aromatic ring with a reactive hydroxyl group and they are classifi ed according to the number and the structural elements linking these rings. They can be found in several plants (mostly in leaves and fruits) and came to public attention when their capacity to fi ght reactive oxygen species (ROS) was discovered. Phenolics (including fl avonoids, anthocyanins, lignins) are secondary metabolites in plants and are important for disease resistance, tolerance to abiotic stress, and for fi ghting bacteria. Tolerance of bacteria for polyphenols depends on the type of bacterium and the structure of the polyphenol.

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Inhibition of Osteoclast Differentiation by Gold Nanoparticles Functionalized with Cyclodextrin Curcumin Complexes

Cited by 114 publications

References 48 publications

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

Development of nanomaterials for bone-targeted drug delivery

Bionanomaterials from Plant Sources

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