Inhibition of nitric oxide synthesis reduces bacterial translocation during graft-versus-host disease after small bowel transplantation

Langrehr, Jan M.; Machens, C; Zill, Edith; Leder, Korinna; Neuhaus, P.

doi:10.1016/s0041-1345(98)01560-7

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…The issue of BT in SBT and the effects on liver and lung biology have been widely studied [16,17]. The unstable graft tolerance in SBT implies the integrity of the intestinal barrier and acute or chronic rejection [18][19][20][21] or graft vs host disease [18,[22][23][24] permeabilize the barrier. These studies have been performed in laboratory rats but the findings are similar to those in bigger mammals like pigs [25,26] or dogs [21].…”

Section: Discussionmentioning

confidence: 99%

Is portal venous outflow better than systemic venous outflow in small bowel transplantation? Experimental study in syngeneic rats

Hernández

Zou

Lopez

et al. 2005

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Is portal venous outflow better than systemic venous outflow in small bowel transplantation? Experimental study in syngeneic rats

Hernández

Zou

Lopez

et al. 2005

Journal of Pediatric Surgery

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Neutropene Kolitis und „Graft-versus-Host-Disease“ (GvHD)

Hoffmann¹

2001

Chronisch Entzündliche Darmerkrankungen

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Peroxynitrite Enhances the Ability of Salmonella dublin to Invade T84 Monolayers

Cornish

Jijon

Yachimec

et al. 2002

Shock

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In the intestine, epithelial cells continually produce and secrete low levels of nitric oxide (NO). Salmonella sp. invade epithelium by responding to environmental stimuli. The aims of this study were to determine the effect of reactive nitrogen intermediates (RNIs) on S. dublin and S. typhimurium growth and invasion of T84 epithelial monolayers. Intracellular NO formation was inhibited by 7-nitroindazole (7-NI) or N(G)-monomethyl-L-arginine, monoacetate (L-NMMA); extracellular NO and peroxynitrite were scavenged with ferro-hemoglobin or urate. The effect of authentic peroxynitrite (ONOO-); 3-morpholino-sydnonimine (SIN-1), which releases ONOO- via NO and superoxide; spermine NONOate, which releases only NO; or superoxide generated by xanthine oxidase and pterin on S. dublin and S. typhimurium growth and invasion were examined. Inhibition of NO synthesis and scavenging of extracellular NO or peroxynitrite reduced S. dublin invasion into T84 monolayers and enhanced bacterial growth. Pre-exposure of S. dublin to ONOO- and SIN-1 increased subsequent bacterial invasion into T84 monolayers. Conversely, exposure of bacteria to spermine NONOate or superoxide did not affect S. dublin invasion. In contrast, S. typhimurium invasion was not affected by pre-treatment with NO donors. In conclusion, exposure of S. dublin to ONOO- enhances the ability of the bacteria to invade epithelial cells. These results suggest that luminal ONOO- may have a novel role as an extracellular signal between invasive bacteria and epithelial cells.

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Inhibition of nitric oxide synthesis reduces bacterial translocation during graft-versus-host disease after small bowel transplantation

Cited by 4 publications

References 5 publications

Is portal venous outflow better than systemic venous outflow in small bowel transplantation? Experimental study in syngeneic rats

Is portal venous outflow better than systemic venous outflow in small bowel transplantation? Experimental study in syngeneic rats

Neutropene Kolitis und „Graft-versus-Host-Disease“ (GvHD)

Peroxynitrite Enhances the Ability of Salmonella dublin to Invade T84 Monolayers

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