Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols

Autore, Giuseppina; Rastrelli, Luca; Lauro, Maria Rosaria; Marzocco, Stefania; Sorrentino, Raffaella; Sorrentino, Ugo; Pinto, Aldo; Aquino, Rita Patrizia

doi:10.1016/s0024-3205(01)01425-4

Cited by 33 publications

(27 citation statements)

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“…Furthermore, their consumption has been associated with the protective effects of certain diets and herbs against some of the complications of hyperuricemia and gout, such as cardiovascular disease and diabetes (Kimira et al, 1998;Sampson et al, 2002). In fact, quercetin and rutin have been reported to possess a wide range of biological activities (Autore et al, 2001;da Silva et al, 2002;Shen et al, 2002;Gerhauser et al, 2003;Moon et al, 2003). It is therefore generally recognized that they appear to be cost effective in hyperuricemic and gouty patients with these disorders.…”

Section: Discussionmentioning

confidence: 99%

Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver

Zhu

Wang

Kong

et al. 2004

Journal of Ethnopharmacology

164

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Section: Discussionmentioning

confidence: 99%

Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver

Zhu

Wang

Kong

et al. 2004

Journal of Ethnopharmacology

164

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“…Thus, compounds that are able to reduce NO production by iNOS without affecting eNOS or nNOS may be desirable as anti-inflammatory agents. Certain flavonoids have been shown to inhibit NO production from macrophage or macrophage-like cells activated with inflammatory stimuli [85][86][87][88][89].…”

Section: No Synthasementioning

confidence: 99%

“…Several studies have shown that some flavonoids inhibit NO production in response to inflammatory stimuli [85][86][87][88][89]. Hämäläinen et al compared the effects of a series of compounds on NO production.…”

Section: Modulation Of Proinflammatory Gene Expressionmentioning

confidence: 99%

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

et al. 2009

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Chronic inflammation is being shown to be increasingly involved in the onset and development of several pathological disturbances such as arteriosclerosis, obesity, diabetes, neurodegenerative diseases and even cancer. Treatment for chronic inflammatory disorders has not been solved, and there is an urgent need to find new and safe anti-inflammatory compounds. Flavonoids belong to a group of natural substances occurring normally in the diet that exhibit a variety of beneficial effects on health. The anti-inflammatory properties of flavonoids have been studied recently, in order to establish and characterize their potential utility as therapeutic agents in the treatment of inflammatory diseases. Several mechanisms of action have been proposed to explain in vivo flavonoid anti-inflammatory actions, such as antioxidant activity, inhibition of eicosanoid generating enzymes or the modulation of the production of proinflammatory molecules. Recent studies have also shown that some flavonoids are modulators of proinflammatory gene expression, thus leading to the attenuation of the inflammatory response. However, much work remains to be done in order to achieve definitive conclusions about their potential usefulness. This review summarizes the known mechanisms involved in the anti-inflammatory activity of flavonoids and the implications of these effects on the protection against cancer and cardiovascular disease.

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“…9) It was also reported that kaempferol exhibits potent in vitro inhibitory eŠects on nitric oxide (NO) release and iNOS expression, whereas kaempferol-3-O-rutinoside (rutin) showed no signiˆcant eŠects even at the highest concentrations. 10) The present study investigated the possible antiin‰ammatory and analgesic eŠects of chloroform, ethyl acetate extracts (EAE), and isolated ‰avonoids from T. chinense Turcz using in vivo experimental models i.e., carrageenan-induced hindpaw edema and xyleneinduced ear edema for antiin‰ammatory activity and the acetic acid-induced abdominal constriction test for analgesic activity.…”

Section: Introductionmentioning

confidence: 99%

Antiinflammatory and Analgesic Activities of <i>Thesium chinense</i> Turcz Extracts and its Major Flavonoids, Kaempferol and Kaempferol-3-<i>O</i>-glucoside

et al. 2007

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The ethyl acetate, chloroform extracts, and the two ‰avonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiin‰ammatory and analgesic activities. For the antiin‰ammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced abdominal constriction test was used. The ethyl acetate extract and two ‰avonoids showed signiˆcant (p＜0.05 and p＜0.01) and dose-dependent antiin‰ammatory and analgesic activity. The chloroform extract was inactive in the assay.

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Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols

Cited by 33 publications

References 0 publications

Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver

Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

Antiinflammatory and Analgesic Activities of <i>Thesium chinense</i> Turcz Extracts and its Major Flavonoids, Kaempferol and Kaempferol-3-<i>O</i>-glucoside

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