Inhibition of Neisseria gonorrhoeae by a Factor Produced by Candida albicans

Hipp, Sally S.; Lawton, William D.; Chen, Norman C.; Gaafar, Hassan A.

doi:10.1128/aem.27.1.192-196.1974

Cited by 31 publications

(12 citation statements)

References 2 publications

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“…The largest percentage of strains of streptococci were inhibitory, fol- (21) Infected lowed by staphylococci and lactobacilli. Other studies using a variety of techniques have demonstrated the in vitro antagonism of N. gonorrhoeae by Candida albicans, staphylococci, Corynebacteria, streptococci, other species of Neisseria, Enterobacteriaceae, and Pseudomonas aeruginosa (10,17,20,24,25,27,30,34). However, very few of these studies provided direct evidence for a protective effect in vivo.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Neisseria gonorrhoeae by aerobic and facultatively anaerobic components of the endocervical flora: evidence for a protective effect against infection

Saigh¹,

Sanders²,

Sanders³

1978

Infect Immun

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The ability of aerobic and facultatively anaerobic endocervical flora to inhibit the growth of Neisseria gonorrhoeae in vitro was assayed. Factors influencing the occurrence of inhibitory components of the flora in vivo were evaluated. Endocervical swabs were obtained from 229 women at a local venereal disease clinic. Endocervical flora and N. gonorrhoeae were isolated and identified, and the ability of the flora to inhibit the growth of N. gonorrhoeae was determined by an agar overlay assay. Results revealed the most active inhibitors to be streptococci, staphylococci, and lactobacilli, in that order. Among only those women harboring inhibitory endocervical flora, inhibitory lactobacilli were recovered from fewer women infected with N. gonorrhoeae than uninfected women (P < 0.05). Among women having contact with an infected partner, those who subsequently developed gonorrhea were less likely to have inhibitory lactobacilli than those who did not become infected (P < 0.05). No other significant differences in the composition of the inhibitory flora were noted between infected and uninfected women. During the 2 weeks following menses, recovery of inhibitory lactobacilli on culture was highest, whereas recovery of N. gonorrhoeae was lowest. These observations suggest that the presence of certain lactobacilli may reduce risk of acquisition of N. gonorrhoeae following exposure to infected partners and that the potential protective effect may be greatest during the 2 weeks after menses.

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Section: Resultsmentioning

confidence: 99%

Inhibition of Neisseria gonorrhoeae by aerobic and facultatively anaerobic components of the endocervical flora: evidence for a protective effect against infection

Saigh¹,

Sanders²,

Sanders³

1978

Infect Immun

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“…gonorrhoeae. Similar inhibition was caused by C. albicans [4] and a number of anaerobes commonly found in the urogenital flora [5]. The nature of these inhibitors of N. gonorrhoeae is less clear but both susceptibility to bacteriocins [6] and shortchain fatty acids [7] have been implicated.…”

Section: Introductionmentioning

confidence: 99%

Interference withHaemophilus influenzaegrowth by other microorganisms

Riley¹,

Hoffman²

1986

FEMS Microbiology Letters

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A total of 97 aerobic and facultatively anaerobic bacteria, and 3 Candida albicans, were tested for their ability to inhibit the growth of Haemophilus influenzae. Only strains of Pseudomonas aeruginosa showed any inhibitory effect and all 5 strains tested clearly inhibited the growth of all 10 strains of H. influenzae. The inhibition of H. influenzae. by Ps. aeruginosa may play a role in the establishment of chronic Ps. aeruginosa infections in the respiratory tracts of patients with bronchiectasis and cystic fibrosis (CF).

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“…In about 30% of the total isolations, C. albicans was recovered, together with bacteria like enterobacteriaceae, enterococci, staphylococci and 6-haemolytic streptococci. In 8 cases, Neisseria gonorrhoeae was also grown although concomitant isolation of C. albicans and gonococci are reported to be rare owing to an inhibitory factor produced by C. albicans (7). Trichomonas vaginalis was detected in only 5 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Morever, it is often difficult to assess the significance of these isolations, particularly in the asymptomatic patient. In the past, high frequencies of isolation from hospital patients have led many authors to regard vaginal yeasts as harmless commensals (4, 5,7). Some prospective studies (1,8), however, have shown that yeasts were not recovered from the normal population as frequently as was generally believed, and their presence, particularly in pregnant women, requires careful consideration for therapy.…”

Section: Introductionmentioning

confidence: 99%

Incidence and Distribution of Vaginal Yeasts in Malaysian Women: Häufigkeit und Verteilung vaginaler Hefen bei malaysischen Frauen

Ngeow

Soo-Hoo

1989

Mycoses

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A total of 2 153 high vaginal swabs were processed for the presence of yeasts. The specimens were obtained from pregnant and non-pregnent Malaysian women with and without vaginitis. The yeast species most commonly isolated were Candida albicans, C. glabrata, C. famata and C.parapsi1osi.s. C. albicanswas isolated from 27 % of pregnant women with vaginitis, 14% of pregnant women with no overt vaginitis, 15 %of non-pregnant women with vaginitis, and 3 % of non-pregnant women with no vaginitis. The significant difference of the isolation rates from women with and without vaginitis indicates that C. albicans is likely to be a vaginal pathogen. Zusammenfassung: Von malaysischen Frauen wurden insgesamt 2153 Abstriche aus dem oberen Scheidenraum auf Hefen untersucht. Die Proben stammten von schwangeren und nicht-schwangeren Frauen mit und ohne Vaginitis. Die am haufigsten isolierten Hefen waren Candida albicans, C. glabrata, C. famata und C. parapsilosis. C. albicans wurde von 27% schwangerer Frauen mit Vaginitis, von 14 % der Schwangeren ohne offensichtliche Va-ginitis, von 15 % nicht-schwangerer Frauen mit Vaginitis und von 3 % Nicht-Schwangerer ohne Vaginitis isoliert. Die signifikante Differenz in den Isolierungsraten von Frauen mit und ohne Vaginitis zeigt, daB C. albicans offensichtlich einen Pathogenitatsfaktor im Vaginalbereich darstellt.

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Inhibition of Neisseria gonorrhoeae by a Factor Produced by Candida albicans

Cited by 31 publications

References 2 publications

Inhibition of Neisseria gonorrhoeae by aerobic and facultatively anaerobic components of the endocervical flora: evidence for a protective effect against infection

Inhibition of Neisseria gonorrhoeae by aerobic and facultatively anaerobic components of the endocervical flora: evidence for a protective effect against infection

Interference withHaemophilus influenzaegrowth by other microorganisms

Incidence and Distribution of Vaginal Yeasts in Malaysian Women: Häufigkeit und Verteilung vaginaler Hefen bei malaysischen Frauen

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