Inhibition of natural killer activity in porcine mononuclear cells by African swine fever virus

An African Swine Fever Virus ERV1-ALR Homologue, 9GL , Affects Virion Maturation and Viral Growth in Macrophages and Viral Virulence in Swine

“…In vivo administration of ALR induced inhibition of NK cell cytotoxic activities in liver by an unknown intermediary mechanism (19). An NK cell response represents one of the earliest host responses to viral infection, and it may be important in the early stages of ASFV infection (42). If p14 functioned as an inhibitor of NK cell activity, either directly or indirectly, it would accelerate viral spread during the early, critical phases of infection.…”

Molecular epidemiology of African swine fever in East Africa

“…Scientist found results which strongly suggested a strong correlation between activation of Natural killer (NK) cell activity and the virulence of the strain (Mendoza et al, 1991;Martins and Leitao, 1994). These cells have not been shown to kill ASFV infected macrophages but the interferon (IFN) they produce may be significant since in vitro studies have shown inhibition of ASFV replication in monocyte/macrophage and cell lines by IFN-γ and IFN-α (Esparza et al, 1988;Paez et al, 1990).…”

Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity

“…Inhibition of NK cell functions appears to be a common feature of viral infections in pigs. Mendoza [28] also found a similar characteristic of NK cells when mononuclear cells were cultured with African swine fever virus (ASFV). Similarly, porcine respiratory and reproduction syndrome virus infection affects the innate immune response of young pigs by inhibiting the function of peripheral blood NK cells [29].…”