“…Many agents have been studied to evaluate their protective effects against cisplatin-induced ototoxicity, including L-methionine, L-N-acetylcysteine, fosfomycin, sodium salicylate, D-methionine, diethyldithiocarbamate, lipoic acid, glutathione ester and epicatechin (Schweitzer et al, 1986;Rybak et al, 1995Rybak et al, , 1999Campbell et al, 1996Campbell et al, , 2003aFeghali et al, 2001;Li et al, 2001Li et al, , 2002Kim et al, 2008). Apocynin, a specific NADPH oxidase inhibitor (Muijsers et al, 2000;Erdos et al, 2006;Chan et al, 2007;Gracia-Sancho et al, 2007;Chirino et al, 2008), has been shown to protect tissue damage in several experimental models (Rugale et al, 2005;Pech et al, 2006;Cui et al, 2007;Chirino et al, 2008). Zebrafish have hair cells on the surface of their body in a sensory system referred to as the lateral line.…”