Inhibition of multiple SARS-CoV-2 variants entry by Lycium barbarum L. polysaccharides through disruption of spike protein-ACE2 interaction

Li, Jingxuan; Liu, Feng; Wu, Fushan; Su, Xiaoyue; Zhang, Lihui; Zhao, Xueru; Shang, Chao; Han, Lu; Zhang, Yongxiang; Xiao, Zhiyong; Zhou, Wenxia

doi:10.1016/j.ijbiomac.2024.129785

Cited by 1 publication

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“…This finding showed the possibility that LBPs could act as inhibitors of SARS-CoV-2 viral invasion. The ultimate objective of this research is to develop a nasal mucosal protective agent that can prevent recurrent viral infections, thereby reducing the risk of long-term complications [ 164 ].…”

Section: Perspective On the Active Ingredients Of Goji Berries In The...mentioning

confidence: 99%

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

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Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as “red Goji berries” or “black Goji berries” due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development.

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Section: Perspective On the Active Ingredients Of Goji Berries In The...mentioning

confidence: 99%

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

View full text Add to dashboard Cite

show abstract

Inhibition of multiple SARS-CoV-2 variants entry by Lycium barbarum L. polysaccharides through disruption of spike protein-ACE2 interaction

Cited by 1 publication

References 39 publications

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

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