Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice

A, Rajeswari; Sabesan, M

doi:10.1007/s10787-007-1614-0

Cited by 155 publications

(85 citation statements)

References 12 publications

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“…These data suggest that the dienone bridge that is present in curcumin, but not in THC, is necessary to reduce plaque deposition and protein oxidation in an Alzheimer model. Rajeswari and Sabesan [57] compared the effects of curcumin with those of THC in a model of Parkinson disease induced in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this model, depletion of dopamine (DA) and DOPAC (3,4-dihydroxy phenyl acetic acid) occurred with increased monoamine oxidase (MAO-B) activity.…”

Section: Neurologic Effectsmentioning

confidence: 99%

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

2014

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Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin. One of the major metabolites of curcumin is tetrahydrocurcumin (THC), which lacks α,β-unsaturated carbonyl moiety and is white in color. Whether THC is superior to curcumin on a molecular level is unclear and thus is the focus of this review. Various studies suggest that curcumin is a more potent antioxidant than THC; curcumin (but not THC) can bind and inhibit numerous targets including DNA (cytosine-5)-methyltransferase-1, heme oxygenase-1, Nrf2, β-catenin, cyclooxygenase-2, NF-kappaB, inducible nitric oxide synthase, nitric oxide, amyloid plaques, reactive oxygen species, vascular endothelial growth factor, cyclin D1, glutathione, P300/CBP, 5-lipoxygenase, cytosolic phospholipase A2, prostaglandin E2, inhibitor of NF-kappaB kinase-1, -2, P38MAPK, p-Tau, tumor necrosis factor-α, forkhead box O3a, CRAC; curcumin can inhibit tumor cell growth and suppress cellular entry of viruses such as influenza A virus and hepatitis C virus much more effectively than THC; curcumin affects membrane mobility; and curcumin is also more effective than THC in suppressing phorbol-ester-induced tumor promotion. Other OPEN ACCESSMolecules 2015, 20 186 studies, however, suggest that THC is superior to curcumin for induction of GSH peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. Most studies have indicated that THC exhibits higher antioxidant activity, but curcumin exhibits both pro-oxidant and antioxidant properties.

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Section: Neurologic Effectsmentioning

confidence: 99%

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

2014

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“…As M. communis leaf extract is rich in polyphenolic compounds such as tannins, it is able to inhibit mono amino oxidase enzyme (MAO) and in this way it can interfere in the action of neurotransmitters in the brain. The use of MAO inhibitors in rats can change TSH release patterns, resulting in decreased transport of iodine [6,7]. Thyroid MAO enzyme is involved in the biosynthesis of thyroid hormones due to its ability to produce hydrogen peroxide [8].…”

Section: Discussionmentioning

confidence: 99%

Effects of Alcoholic Extract of Myrtus communis L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats

Changizi-Ashtiyani

Shariati

Mokhtari

et al. 2015

Zahedan J Res Med Sci

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Background:Myrtus communis leaves have the potential to affect thyroid hormone functions. Objectives: In this study, the effects of hydroalcoholic extract of M. communis on the hypothalamus-pituitary-thyroid axis and histological changes were studied. Materials and Methods:In this experimental study, 40 male rats were divided in 5 groups (n = 8): control, sham, and three experimental groups which received the extract of M. communis leaves in a minimal (0.75 mg/kg), Medium (1.5 mg/kg) and maximal amounts (3 mg/ kg), respectively. At the end of the 15th day blood samples were collected to measure triiodothyronine (T 3 ), thyroxine (T 4 ) and thyroidstimulating hormone (TSH) and to study thyroid gland tissue Results: Serum levels of T 4 and TSH in groups receiving maximum dose of the extract showed a significant decrease compared to sham group (P < 0.05). Conclusions: It is probable that some compounds in the alcoholic extract of M. communis leaves may be cause changes in serum TSH concentration and thyroid hormones.

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“…It has been reported that tetrahydrocurcumin possesses hepatoprotective effects against chloroquine-induced hepatotoxicity in rats by decreasing the levels of enzymatic and non-enzymatic antioxidant activities (Murugavel and Pari 2004;Pari and Amali 2005). In neurogenerative disorders, tetrahydrocurcumin increases the level of dopamine through the inhibition of monoamine oxidase activity in an animal model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (Rajeswari and Sabesan 2008). Moreover, tetrahydrocurcumin reduces amyloid-β-induced oxidative stress and neurotoxicity by regenerating the mitochondrial membrane potential and inhibiting ROS generation and casspase-3 activity in rat hippocampal and human neuronal cells (Mishra et al 2011).…”

Section: Tetrahydrocurcuminmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

Kukongviriyapan

Apaijit

Kukongviriyapan

2016

Tohoku J. Exp. Med.

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Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and nephropathy, all of which could be attributable to dysfunctional endothelial and smooth muscle cells. Cd toxicity is correlated with increased reactive oxygen formation and depletion of antioxidants, resulting in an oxidative stress. Chelation of Cd has proved useful in the removal of the Cd burden. However, several chelating agents cause side effects in clinical usage. Recent studies have shown that the antioxidant compounds curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by Cd toxicity. In chronic Cd exposure, these antioxidants protect vascular endothelium by increasing nitric oxide (NO•) bioavailability and improving vascular function. Antioxidant activity against Cd intoxication results directly and/or indirectly through free radical scavenging, metal chelation, enhanced expression of the antioxidant defense system, regulation of inflammatory enzymes, increase in NO• bioavailability, and reduction of gastrointestinal absorption and tissue Cd accumulation. This review summarizes current knowledge of Cd-induced oxidative stress and cardiovascular dysfunction and a possible protective effect conferred by the antioxidants curcumin and tetrahydrocurcumin.

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Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice

Cited by 155 publications

References 12 publications

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

Effects of Alcoholic Extract of Myrtus communis L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

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