Inhibition of MMPs might increase anticancer properties of amniotic epithelial cells

Blood compatibility of human amniotic membrane compared with heparin-coated ePTFE for vascular tissue engineering

“…Experimental and clinical studies have currently demonstrated that the AM has many features, including antibacterial properties (King et al ., ; Tehrani et al ., ), low immunogenicity (Hori et al ., ) and anti‐cancer features (Niknejad et al ., , , ). It also promotes re‐epithelialization, decreases the inflammatory process and modulates angiogenesis (Seifalian et al ., ; Niknejad et al ., ).…”

Different Light Transmittance of Placental and Reflected Regions of Human Amniotic Membrane That Could Be Crucial for Corneal Tissue Engineering

“…2,3 Furthermore, the AM has been shown to have antifibrotic, anticancer, and angio-modulatory effects, which make it suitable for use in a variety of clinical fields. [4][5][6] The AM has been used for ocular surface reconstruction 7 such as constant corneal epithelial defects or ulcerations, chemical burns, Stevens-Johnsons syndrome, 8 bullous keratopathies, 9 and pterygium. 10 Moreover, limbal epithelial cells cultivated on AM have been used for limbal epithelial stem cell deficiencies.…”

Role of Stem Cells in the Anti-tumor Effects of the Human Amniotic Membrane

“…They suggested pro-apoptotic activities as well as anti-angiogenic and immunoregulatory capacities for the AM and argued that these properties can be applicable in cancer therapy. The hypothesised anti-cancer effects of the AM was further discussed and evaluated by Niknejad et al [5,9], Jiao et al [10] and Magatti et al [11].…”

“…Providing a proper blood supply for tumor cells is a key element in tumor growth and metastasis [5] and the AM is believed to possess anti-angiogenesis properties [5,6,8,9,12]. There are reports of antiangiogenic factors such as collagen XVIII, thrombospondin-1, interleukin (IL)-1 receptor antagonist, IL-10 and tissue inhibitor of metalloprotease (TIMP-1, TIMP-2, TIMP-3, and TIMP-4) being mainly produced by the AM-derived Epithelial Stem Cells [12].…”