Inhibition of mitomycin C-induced sister-chromatid exchanges in mouse bone marrow cells by the immunopotentiators Krestin and Lentinan

Hasegawa, Junji; Hosokawa, Masuo; Okada, Futoshi; Kobayashi, Hiroshi

doi:10.1016/0165-7992(89)90086-9

Cited by 12 publications

(3 citation statements)

References 4 publications

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“…Mice were acclimatized for 2 days and divided into nine groups consisting of 5 mice each, set up as follows: Group 1: mice served as a control group and treated daily with saline only for 2 consecutive days; Groups 2 and 3: mice were treated with LAN in a dose of 1 or 2 mg/kg, respectively, once a day, for 2 consecutive days; Group 4: mice were injected with a single dose of 1 mg/kg PAC alone; Groups 5 and 6: mice were treated with LAN at a dose of 1 or 2 mg/kg/day, respectively, once a day, for 2 consecutive days and 1 mg/kg of PAC was administrated on the day 2, 1 h after regular LAN exposure; Group 7: mice were injected with a single dose of 2 mg/kg PAC alone; Groups 8 and 9: mice were treated with LAN at a dose of 1 or 2 mg/kg/day, respectively, once a day, for 2 consecutive days and 2 mg/kg of PAC was administrated on the day 2, 1 h after regular LAN exposure. The doses of PAC were selected on the basis of its effectiveness in inducing DNA damage , while the anti‐genotoxic doses for LAN were chosen by reference to the earlier study . After drug administration, the animals were maintained with food and water ad libitum until being sacrificed.…”

Section: Methodsmentioning

confidence: 99%

The Influence of Lentinan on the Capacity of Repair of DNA Damage and Apoptosis Induced by Paclitaxel in Mouse Bone Marrow Cells

Attia

Harisa

Abd-Allah

et al. 2013

J Biochem & Molecular Tox

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The ability of the flavonoid lentinan (LAN) to enhance the repair of paclitaxel (PAC)-induced DNA damage and apoptosis in mouse bone marrow cells was investigated. Moreover, the possible mechanism underlying this modulation was determined. LAN was neither genotoxic nor apoptogenic at doses equivalent to 1 or 2 mg/kg/day. Pretreatment of mice with LAN significantly enhances the repair of PAC-induced DNA damage and bone marrow suppression in a dose dependent manner. Moreover, LAN affords significant protection against PAC-induced apoptosis. A significant increase of reactive oxygen species and a decrease in reduced glutathione levels were observed after PAC treatment and prior administration of LAN before PAC challenge ameliorated these oxidative stress markers. Conclusively, our study provides, for the first time, that LAN enhances the repair of PAC-induced DNA damage and apoptosis that resides, at least in part, on its ability to modulate the cellular antioxidant levels and consequently protect bone marrow cells from PAC genotoxicity.

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Section: Methodsmentioning

confidence: 99%

The Influence of Lentinan on the Capacity of Repair of DNA Damage and Apoptosis Induced by Paclitaxel in Mouse Bone Marrow Cells

Attia

Harisa

Abd-Allah

et al. 2013

J Biochem & Molecular Tox

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“…For Yunzhi animal studies, cisplatin-induced renal damage was reduced by decreasing blood urea nitrogen (BUN) and serum creatinine (Scr) levels [166]. In both animal and in-vitro studies, PSK reduced the mutagenicity of mitomycin by decreasing the frequency of sister chromatid exchange and micronuclei formation [187,188].…”

Section: B Preclinical and Mechanistic Evidencementioning

confidence: 99%

Herb–drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review

et al. 2020

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Background: Lingzhi and Yunzhi are medicinal mushrooms commonly used with cytotoxic chemotherapy in cancer patients in Asian countries. The current systematic review aims to identify potential pharmacokinetic or pharmacodynamic interactions from the existing literature to ensure their effective and safe combination usage in cancer patients. Methods: A systematic search was conducted on nine major Chinese and English databases, including China Journal Net, Allied and Complementary Medicine Database, and Ovid MEDLINE ® , etc., to identify clinical, animal, and in-vitro studies that evaluate the effect of combined use of Lingzhi or Yunzhi with cytotoxic drugs. The Jadad scale was used to assess the quality of clinical studies. Results: This search identified 213 studies, including 77 clinical studies that reported on the combined use of cytotoxic drugs with Yunzhi (n = 56) or Lingzhi (n = 21). Majority of these clinical studies demonstrated modest methodological quality. In clinical practice, the most commonly used cytotoxic drugs with Lingzhi were cisplatin, 5-fluorouracil (5-FU) and paclitaxel, whereas Tegafur/uracil (UFT)/Tegafur, 5-FU, and mitomycin were the ones used more often with Yunzhi. Only two clinical pharmacokinetic studies were available showing no significant interactions between Polysaccharide K (PSK) and Tegafur. From the pharmacodynamic interactions perspective, combination uses of Yunzhi/Lingzhi with cytotoxic drugs in clinical practice could lead to improvement in survival (n = 31) and quality of life (n = 17), reduction in tumor lesions (n = 22), immune modulation (n = 38), and alleviation of chemotherapy-related side effects (n = 14) with no reported adverse effects. Conclusion: Our findings suggest that the clinical combination use of Lingzhi or Yunzhi with cytotoxic drugs could enhance the efficacy and ameliorate the adverse effects of cytotoxic drugs, leading to improved quality of life in cancer patients. More high quality clinical studies including pharmacokinetic herb-drug interactions studies are warranted to verify these observations and mechanisms involved. Based on the high quality clinical data, pharmacoepidemiology methods and bioinformatics or data mining could be adopt for further identification of clinical meaningful herb-drug interactions in cancer therapies.

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“…Studies have pointed out that the mushroom Lentinula edodes and some of its active substances exert a protective effect against mutagenesis and carcinogenesis [45][46][47]. L. edodes also was observed to be effective in protecting against DNA damage, which can be responsible for the initiation of carcinogenesis.…”

Section: Plants As Protective Agents Against Dna Damagementioning

confidence: 99%

Mutagenicity and Antimutagenicity of Medicinal Plants

Musarrat

Aqil

Ahmad

2006

Modern Phytomedicine

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Plants synthesize an array of structurally and functionally diverse bioactive secondary metabolites. These phytocompounds are subject to wide experimental scrutiny for their pharmacological and therapeutic potential. Substantial work has been reported on the screening of medicinal and edible plants for their mutagenicity and/or antimutagenic properties. Most of these natural products are regarded as potential sources of novel therapeutic agents against mutational disorders in humans. For a successful screening program, it is essential to evaluate critically the biological activity of plant extracts through appropriate assay systems. This chapter presents information related to traditionally used medicinal and edible plants endowed with a variety of phytochemicals conferring mutagenicity and antimutagenicity. 13.1

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Inhibition of mitomycin C-induced sister-chromatid exchanges in mouse bone marrow cells by the immunopotentiators Krestin and Lentinan

Cited by 12 publications

References 4 publications

The Influence of Lentinan on the Capacity of Repair of DNA Damage and Apoptosis Induced by Paclitaxel in Mouse Bone Marrow Cells

The Influence of Lentinan on the Capacity of Repair of DNA Damage and Apoptosis Induced by Paclitaxel in Mouse Bone Marrow Cells

Herb–drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review

Mutagenicity and Antimutagenicity of Medicinal Plants

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