Inhibition of mitochondrial cytochrome c oxidase by dicarbanonaborates

Abstract

SUMMARYDicarbanonaborates inhibit the mitochondrial Wtochrome c oxidase activity. In contrast to mitochondrial ATPase or glycerol phosphate dehydrogenase, inhibition of cytochrome c oxidase was not competitive and the residual, drag-insensitive activity was higher. These results indicate that dicarbanonaborates inhibit various mitochondrial membrane-bound enzymes through different mechanisms.